ID   SOX8_CHICK              Reviewed;         470 AA.
AC   P57074;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Transcription factor SOX-8;
GN   Name=SOX8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=10842083; DOI=10.1016/s0925-4773(00)00296-3;
RA   Bell K.M., Western P.S., Sinclair A.H.;
RT   "SOX8 expression during chick embryogenesis.";
RL   Mech. Dev. 94:257-260(2000).
CC   -!- FUNCTION: Transcription factor that may play a role in central nervous
CC       system, limb and facial development. May be involved in male sex
CC       determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
CC       {ECO:0000250|UniProtKB:Q04886}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: Widely expressed in the embryo.
CC       {ECO:0000269|PubMed:10842083}.
CC   -!- DOMAIN: The transactivation domains TAM and TAC (for transactivation
CC       domain in the middle and at the C-terminus, respectively) are required
CC       to contact transcriptional coactivators and basal transcriptional
CC       machinery components and thereby induce gene transactivation.
CC       {ECO:0000250|UniProtKB:P48436}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P57073}.
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DR   EMBL; AF228664; AAF73917.1; -; mRNA.
DR   RefSeq; NP_990062.1; NM_204731.1.
DR   AlphaFoldDB; P57074; -.
DR   SMR; P57074; -.
DR   STRING; 9031.ENSGALP00000008435; -.
DR   PaxDb; P57074; -.
DR   GeneID; 395483; -.
DR   KEGG; gga:395483; -.
DR   CTD; 30812; -.
DR   VEuPathDB; HostDB:geneid_395483; -.
DR   eggNOG; KOG0527; Eukaryota.
DR   InParanoid; P57074; -.
DR   OrthoDB; 782373at2759; -.
DR   PhylomeDB; P57074; -.
DR   PRO; PR:P57074; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0003170; P:heart valve development; IEP:UniProtKB.
DR   GO; GO:0048709; P:oligodendrocyte differentiation; IEP:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR031265; SOX-8.
DR   InterPro; IPR022151; Sox_N.
DR   PANTHER; PTHR45803:SF2; PTHR45803:SF2; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12444; Sox_N; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..470
FT                   /note="Transcription factor SOX-8"
FT                   /id="PRO_0000048735"
FT   DNA_BIND        109..177
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..107
FT                   /note="Dimerization (DIM)"
FT                   /evidence="ECO:0000250|UniProtKB:P57073"
FT   REGION          163..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..308
FT                   /note="Transactivation domain (TAM)"
FT                   /evidence="ECO:0000250|UniProtKB:P57073"
FT   REGION          327..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..470
FT                   /note="Transactivation domain (TAC)"
FT                   /evidence="ECO:0000250|UniProtKB:P57073"
FT   MOTIF           424..432
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P57073"
FT   COMPBIAS        17..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   470 AA;  50830 MW;  020ADD008AFA4334 CRC64;
     MLNMTEEHDK ALEAPCSPAG TTSSMSHVDS DSDSPLSPAG SEGLGCAPAP APRPPGAAPL
     GAKVDAAEVD ERFPACIRDA VSQVLKGYDW SLVPMPVRGN GSLKAKPHVK RPMNAFMVWA
     QAARRKLADQ YPHLHNAELS KTLGKLWRLL SENEKRPFVE EAERLRVQHK KDHPDYKYQP
     RRRKSVKAGQ SDSDSGAELS HHAGTQIYKA DSGLGGMADG HHHGEHAGQP HGPPTPPTTP
     KTDLHHGSKQ ELKHEGRRLV ESGRQNIDFS NVDISELSSE VINNMETFDV HEFDQYLPLN
     GHTAMPADHG PGAGFYSTSY SHSAAGAGGA GQVWTHKSPA SASPSSADSG QQRPHIKTEQ
     LSPSHYSDQS HGSPAHSDYG SYSTQACATT ASTATAAASF SSSQCDYTDL QSSNYYNPYP
     GYPSSIYQYP YFHSSRRPYA TPILNGLSIP PAHSPTANWD QPVYTTLTRP