SOX8_MOUSE
ID SOX8_MOUSE Reviewed; 464 AA.
AC Q04886;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Transcription factor SOX-8 {ECO:0000305};
GN Name=Sox8 {ECO:0000303|PubMed:10684944, ECO:0000312|MGI:MGI:98370};
GN Synonyms=Sox-8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=129/Sv;
RX PubMed=10684944; DOI=10.1093/nar/28.6.1473;
RA Schepers G.E., Bullejos M., Hosking B.M., Koopman P.;
RT "Cloning and characterisation of the Sry-related transcription factor gene
RT Sox8.";
RL Nucleic Acids Res. 28:1473-1480(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 107-162.
RX PubMed=8441686; DOI=10.1093/nar/21.3.744;
RA Wright E.M., Snopek B., Koopman P.;
RT "Seven new members of the Sox gene family expressed during mouse
RT development.";
RL Nucleic Acids Res. 21:744-744(1993).
CC -!- FUNCTION: Transcription factor that may play a role in central nervous
CC system, limb and facial development. May be involved in male sex
CC determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
CC {ECO:0000269|PubMed:10684944}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Brain, gut, limb, and testes. Slightly in liver,
CC ovaries, spinal cord, lung and heart.
CC -!- DOMAIN: The transactivation domains TAM and TAC (for transactivation
CC domain in the middle and at the C-terminus, respectively) are required
CC to contact transcriptional coactivators and basal transcriptional
CC machinery components and thereby induce gene transactivation.
CC {ECO:0000250|UniProtKB:P48436}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P57073}.
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DR EMBL; AF191325; AAF35837.1; -; Genomic_DNA.
DR EMBL; BC085619; AAH85619.1; -; mRNA.
DR EMBL; Z18957; CAA79482.1; -; mRNA.
DR CCDS; CCDS28521.1; -.
DR PIR; S30246; S30246.
DR RefSeq; NP_035577.1; NM_011447.3.
DR AlphaFoldDB; Q04886; -.
DR SMR; Q04886; -.
DR BioGRID; 203412; 15.
DR IntAct; Q04886; 1.
DR STRING; 10090.ENSMUSP00000025003; -.
DR iPTMnet; Q04886; -.
DR PhosphoSitePlus; Q04886; -.
DR PaxDb; Q04886; -.
DR PRIDE; Q04886; -.
DR ProteomicsDB; 261119; -.
DR Antibodypedia; 9438; 361 antibodies from 36 providers.
DR DNASU; 20681; -.
DR Ensembl; ENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
DR GeneID; 20681; -.
DR KEGG; mmu:20681; -.
DR UCSC; uc008bay.1; mouse.
DR CTD; 30812; -.
DR MGI; MGI:98370; Sox8.
DR VEuPathDB; HostDB:ENSMUSG00000024176; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000159920; -.
DR HOGENOM; CLU_031800_0_0_1; -.
DR InParanoid; Q04886; -.
DR OMA; MLNMTEE; -.
DR OrthoDB; 782373at2759; -.
DR PhylomeDB; Q04886; -.
DR TreeFam; TF351735; -.
DR BioGRID-ORCS; 20681; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Sox8; mouse.
DR PRO; PR:Q04886; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q04886; protein.
DR Bgee; ENSMUSG00000024176; Expressed in epithelium of gonad and 153 other tissues.
DR ExpressionAtlas; Q04886; baseline and differential.
DR Genevisible; Q04886; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0060612; P:adipose tissue development; IMP:MGI.
DR GO; GO:0060018; P:astrocyte fate commitment; IGI:MGI.
DR GO; GO:0045165; P:cell fate commitment; IGI:MGI.
DR GO; GO:0048469; P:cell maturation; IMP:MGI.
DR GO; GO:0048484; P:enteric nervous system development; IMP:UniProtKB.
DR GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
DR GO; GO:0008584; P:male gonad development; IGI:MGI.
DR GO; GO:0072289; P:metanephric nephron tubule formation; IGI:MGI.
DR GO; GO:0061138; P:morphogenesis of a branching epithelium; IGI:MGI.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
DR GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IGI:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0014032; P:neural crest cell development; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IMP:UniProtKB.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
DR GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
DR GO; GO:0007422; P:peripheral nervous system development; IGI:MGI.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IGI:MGI.
DR GO; GO:0014015; P:positive regulation of gliogenesis; IMP:UniProtKB.
DR GO; GO:0090184; P:positive regulation of kidney development; IGI:UniProtKB.
DR GO; GO:0033690; P:positive regulation of osteoblast proliferation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0010817; P:regulation of hormone levels; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072034; P:renal vesicle induction; IMP:UniProtKB.
DR GO; GO:0060041; P:retina development in camera-type eye; IGI:MGI.
DR GO; GO:0060221; P:retinal rod cell differentiation; IGI:MGI.
DR GO; GO:0060009; P:Sertoli cell development; IGI:MGI.
DR GO; GO:0007165; P:signal transduction; IMP:UniProtKB.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR GO; GO:0072197; P:ureter morphogenesis; IGI:MGI.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR031265; SOX-8.
DR InterPro; IPR022151; Sox_N.
DR PANTHER; PTHR45803:SF2; PTHR45803:SF2; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12444; Sox_N; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..464
FT /note="Transcription factor SOX-8"
FT /id="PRO_0000048734"
FT DNA_BIND 99..167
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..97
FT /note="Dimerization (DIM)"
FT /evidence="ECO:0000250|UniProtKB:P57073"
FT REGION 154..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..299
FT /note="Transactivation domain (TAM)"
FT /evidence="ECO:0000250|UniProtKB:P57073"
FT REGION 292..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..464
FT /note="Transactivation domain (TAC)"
FT /evidence="ECO:0000250|UniProtKB:P57073"
FT REGION 354..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 418..426
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P57073"
FT COMPBIAS 11..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 49879 MW; 3C080629F58F5AB5 CRC64;
MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR GDTAEAADER
FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK RPMNAFMVWA QAARRKLADQ
YPHLHNAELS KTLGKLWRLL SESEKRPFVE EAERLRVQHK KDHPDYKYQP RRRKSVKTGR
SDSDSGTELG HHPGGPMYKA DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK
QELRLEGRRL VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP
SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI KTEQLSPSHY
NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD YTDLQASNYY SPYPGYPPSL
YQYPYFHSSR RPYASPLLNG LSMPPAHSPS SNWDQPVYTT LTRP
