SOXR_PSEAE
ID SOXR_PSEAE Reviewed; 156 AA.
AC Q51506;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Redox-sensitive transcriptional activator SoxR;
GN Name=soxR; OrderedLocusNames=PA2273;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=9045804; DOI=10.1128/jb.179.5.1490-1496.1997;
RA Liao X., Hancock R.E.W.;
RT "Identification of a penicillin-binding protein 3 homolog, PBP3x, in
RT Pseudomonas aeruginosa: gene cloning and growth phase-dependent
RT expression.";
RL J. Bacteriol. 179:1490-1496(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Activates the transcription of the soxS gene which itself
CC controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-
CC sulfur cluster that may act as a redox sensor system that recognizes
CC superoxide. The variable redox state of the Fe-S cluster is employed in
CC vivo to modulate the transcriptional activity of SoxR in response to
CC specific types of oxidative stress (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; X95517; CAA64771.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG05661.1; -; Genomic_DNA.
DR PIR; B83361; B83361.
DR RefSeq; NP_250963.1; NC_002516.2.
DR RefSeq; WP_003089301.1; NZ_QZGE01000014.1.
DR AlphaFoldDB; Q51506; -.
DR SMR; Q51506; -.
DR STRING; 287.DR97_6160; -.
DR PaxDb; Q51506; -.
DR PRIDE; Q51506; -.
DR EnsemblBacteria; AAG05661; AAG05661; PA2273.
DR GeneID; 882298; -.
DR KEGG; pae:PA2273; -.
DR PATRIC; fig|208964.12.peg.2375; -.
DR PseudoCAP; PA2273; -.
DR HOGENOM; CLU_060077_5_1_6; -.
DR InParanoid; Q51506; -.
DR OMA; IHFYEAK; -.
DR PhylomeDB; Q51506; -.
DR BioCyc; PAER208964:G1FZ6-2312-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd01110; HTH_SoxR; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR010211; Redox-sen_tscrpt-act_SoxR.
DR InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR PANTHER; PTHR30204:SF0; PTHR30204:SF0; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF09278; MerR-DNA-bind; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR TIGRFAMs; TIGR01950; SoxR; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Activator; DNA-binding; Iron; Iron-sulfur; Metal-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..156
FT /note="Redox-sensitive transcriptional activator SoxR"
FT /id="PRO_0000098155"
FT DOMAIN 9..77
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 12..31
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT REGION 117..128
FT /note="Might be part of a sensor region"
FT BINDING 117
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 120
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 122
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 128
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
SQ SEQUENCE 156 AA; 16998 MW; 7B542A23804D72C2 CRC64;
MKNSCASREL SVGELARRAG VAVSALHFYE TKGLISSQRN AGNQRRFSRE TLRRVVVIKV
AQRVGIPLAE IARALQTLPA GRSPSAADWA RLSAQWKEDL TERIDKLLLL RDQLDGCIGC
GCLSLQACPL RNPGDQLSAE GPGAHWLDAE GREHDG
