SOXS_ECOLI
ID SOXS_ECOLI Reviewed; 107 AA.
AC P0A9E2; P22539; Q2M6P2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Regulatory protein SoxS;
GN Name=soxS; OrderedLocusNames=b4062, JW4023;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1708380; DOI=10.1128/jb.173.9.2864-2871.1991;
RA Wu J., Weiss B.;
RT "Two divergently transcribed genes, soxR and soxS, control a superoxide
RT response regulon of Escherichia coli.";
RL J. Bacteriol. 173:2864-2871(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1653416; DOI=10.1093/nar/19.16.4479;
RA Amabile-Cuevas C.F., Demple B.;
RT "Molecular characterization of the soxRS genes of Escherichia coli: two
RT genes control a superoxide stress regulon.";
RL Nucleic Acids Res. 19:4479-4484(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT from 89.2 to 92.8 minutes.";
RL Nucleic Acids Res. 21:5408-5417(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP PROTEIN SEQUENCE OF 2-12, AND CHARACTERIZATION.
RC STRAIN=K12 / XA90;
RX PubMed=8034583; DOI=10.1016/s0021-9258(17)32317-7;
RA Li Z., Demple B.;
RT "SoxS, an activator of superoxide stress genes in Escherichia coli.
RT Purification and interaction with DNA.";
RL J. Biol. Chem. 269:18371-18377(1994).
CC -!- FUNCTION: Transcriptional activator of the superoxide response regulon
CC of E.coli that includes at least 10 genes such as sodA, nfo, zwf and
CC micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the
CC subsequent binding of RNA polymerase to the micF and the nfo promoters.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: By paraquat.
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DR EMBL; M60111; AAA24640.1; -; Genomic_DNA.
DR EMBL; X59593; CAA42161.1; -; Genomic_DNA.
DR EMBL; U00006; AAC43156.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77032.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78064.1; -; Genomic_DNA.
DR PIR; JS0578; JS0578.
DR RefSeq; NP_418486.1; NC_000913.3.
DR RefSeq; WP_000019358.1; NZ_STEB01000014.1.
DR AlphaFoldDB; P0A9E2; -.
DR SMR; P0A9E2; -.
DR BioGRID; 4262018; 126.
DR BioGRID; 852861; 1.
DR DIP; DIP-10904N; -.
DR IntAct; P0A9E2; 10.
DR STRING; 511145.b4062; -.
DR PaxDb; P0A9E2; -.
DR PRIDE; P0A9E2; -.
DR EnsemblBacteria; AAC77032; AAC77032; b4062.
DR EnsemblBacteria; BAE78064; BAE78064; BAE78064.
DR GeneID; 67414699; -.
DR GeneID; 948567; -.
DR KEGG; ecj:JW4023; -.
DR KEGG; eco:b4062; -.
DR PATRIC; fig|511145.12.peg.4183; -.
DR EchoBASE; EB0951; -.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_000445_81_14_6; -.
DR InParanoid; P0A9E2; -.
DR OMA; FTMAWTR; -.
DR PhylomeDB; P0A9E2; -.
DR BioCyc; EcoCyc:PD00406; -.
DR PRO; PR:P0A9E2; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001108; F:bacterial-type RNA polymerase holo enzyme binding; IDA:EcoCyc.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:EcoCyc.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF12833; HTH_18; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; Direct protein sequencing; DNA-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8034583"
FT CHAIN 2..107
FT /note="Regulatory protein SoxS"
FT /id="PRO_0000194583"
FT DOMAIN 8..106
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 25..46
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 73..96
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 107 AA; 12911 MW; 7341326FBAB819D6 CRC64;
MSHQKIIQDL IAWIDEHIDQ PLNIDVVAKK SGYSKWYLQR MFRTVTHQTL GDYIRQRRLL
LAAVELRTTE RPIFDIAMDL GYVSQQTFSR VFRRQFDRTP SDYRHRL
