SOX_CAEEL
ID SOX_CAEEL Reviewed; 384 AA.
AC Q18006;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Putative sarcosine oxidase;
DE EC=1.5.3.1;
GN ORFNames=C15B12.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O2 + sarcosine = formaldehyde + glycine + H2O2;
CC Xref=Rhea:RHEA:13313, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:57305,
CC ChEBI:CHEBI:57433; EC=1.5.3.1;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC Note=Binds 1 FAD per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the MSOX/MTOX family. {ECO:0000305}.
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DR EMBL; FO080547; CCD64563.1; -; Genomic_DNA.
DR RefSeq; NP_509092.2; NM_076691.4.
DR AlphaFoldDB; Q18006; -.
DR SMR; Q18006; -.
DR STRING; 6239.C15B12.1; -.
DR EPD; Q18006; -.
DR PaxDb; Q18006; -.
DR PeptideAtlas; Q18006; -.
DR EnsemblMetazoa; C15B12.1.1; C15B12.1.1; WBGene00015783.
DR GeneID; 180921; -.
DR KEGG; cel:CELE_C15B12.1; -.
DR UCSC; C15B12.1; c. elegans.
DR CTD; 180921; -.
DR WormBase; C15B12.1; CE29665; WBGene00015783; -.
DR eggNOG; KOG2820; Eukaryota.
DR GeneTree; ENSGT00390000011000; -.
DR HOGENOM; CLU_007884_2_2_1; -.
DR InParanoid; Q18006; -.
DR OMA; QEQPAHF; -.
DR OrthoDB; 752680at2759; -.
DR PhylomeDB; Q18006; -.
DR Reactome; R-CEL-71064; Lysine catabolism.
DR Reactome; R-CEL-9033241; Peroxisomal protein import.
DR PRO; PR:Q18006; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00015783; Expressed in material anatomical entity and 3 other tissues.
DR GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0050031; F:L-pipecolate oxidase activity; ISS:UniProtKB.
DR GO; GO:0008115; F:sarcosine oxidase activity; ISS:UniProtKB.
DR GO; GO:0033514; P:L-lysine catabolic process to acetyl-CoA via L-pipecolate; ISS:UniProtKB.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR045170; MTOX.
DR PANTHER; PTHR10961; PTHR10961; 1.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT CHAIN 1..384
FT /note="Putative sarcosine oxidase"
FT /id="PRO_0000213776"
FT BINDING 6..36
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT MOD_RES 315
FT /note="S-8alpha-FAD cysteine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 43123 MW; DB0BF3156F51A6C2 CRC64;
MSTDYDVVVV GAGIFGSCTA YNCQKIGLKT LLLEQFELGH KNGSSHGKSR ITRYAHTEVE
YVDLVGDAYN QIFELERIRG EKLWKKTGLL WVSTGNEVEK IHTNLKLKGI KHEVIKGTEV
GKRYPQFKFD DSWNGLIDPM GGVIYADKWL NAFRDEFKKI GGIIHDREIV LSHSEISNNL
FVTTNKSRYS SKKIIFTVGC WITKFLPDLK FNIEPISISV CYWKTKNESD SHLLNEDHYP
VVIAQEMDLQ VFHYSLPDTD YPGSMKFCYH FGDALTQDLA HPAQRSQRCI DLPAKFIQKY
MPVVDGSAPT RIDKCIYTNS PDDHYIIGTI PTKNPNILVG GCGSGSGFKV APGIGKALAE
MAAGKKTTVD VSFFSANRFK PSKI
