SOYB_DROME
ID SOYB_DROME Reviewed; 1476 AA.
AC Q9VL52; E0R964;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Putative ATP-dependent RNA helicase SoYb;
DE EC=3.6.4.13;
DE AltName: Full=Sister of Yb;
GN Name=SoYb; ORFNames=CG31755;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-304.
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21863019; DOI=10.1038/emboj.2011.308;
RA Handler D., Olivieri D., Novatchkova M., Gruber F.S., Meixner K.,
RA Mechtler K., Stark A., Sachidanandam R., Brennecke J.;
RT "A systematic analysis of Drosophila TUDOR domain-containing proteins
RT identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway
RT factors.";
RL EMBO J. 30:3977-3993(2011).
CC -!- FUNCTION: Involved in primary piRNA biogenesis in germline cells.
CC {ECO:0000269|PubMed:21863019}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21863019}.
CC Note=Localizes to Yb bodies.
CC -!- SEQUENCE CAUTION:
CC Sequence=ADM35111.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF52845.3; -; Genomic_DNA.
DR EMBL; AE014134; AFH03633.1; -; Genomic_DNA.
DR EMBL; BT125632; ADM35111.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001245959.1; NM_001259030.2.
DR RefSeq; NP_609335.3; NM_135491.5.
DR AlphaFoldDB; Q9VL52; -.
DR SMR; Q9VL52; -.
DR BioGRID; 60425; 12.
DR IntAct; Q9VL52; 6.
DR MINT; Q9VL52; -.
DR STRING; 7227.FBpp0292885; -.
DR PaxDb; Q9VL52; -.
DR PRIDE; Q9VL52; -.
DR EnsemblMetazoa; FBtr0303882; FBpp0292885; FBgn0051755.
DR EnsemblMetazoa; FBtr0308122; FBpp0300444; FBgn0051755.
DR GeneID; 34331; -.
DR KEGG; dme:Dmel_CG31755; -.
DR UCSC; CG31755-RA; d. melanogaster.
DR CTD; 34331; -.
DR FlyBase; FBgn0051755; SoYb.
DR VEuPathDB; VectorBase:FBgn0051755; -.
DR eggNOG; KOG0334; Eukaryota.
DR GeneTree; ENSGT00940000167250; -.
DR HOGENOM; CLU_004169_0_0_1; -.
DR InParanoid; Q9VL52; -.
DR OMA; QQHSHWL; -.
DR OrthoDB; 85564at2759; -.
DR PhylomeDB; Q9VL52; -.
DR SignaLink; Q9VL52; -.
DR BioGRID-ORCS; 34331; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34331; -.
DR PRO; PR:Q9VL52; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0051755; Expressed in egg cell and 15 other tissues.
DR ExpressionAtlas; Q9VL52; baseline and differential.
DR Genevisible; Q9VL52; DM.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0070725; C:Yb body; IDA:FlyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0042078; P:germ-line stem cell division; IBA:GO_Central.
DR GO; GO:0010526; P:negative regulation of transposition, RNA-mediated; IGI:FlyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00567; TUDOR; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Helicase; Hydrolase; Nucleotide-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..1476
FT /note="Putative ATP-dependent RNA helicase SoYb"
FT /id="PRO_0000425215"
FT DOMAIN 8..117
FT /note="Tudor 1"
FT DOMAIN 502..649
FT /note="Helicase ATP-binding"
FT DOMAIN 929..1043
FT /note="Tudor 2"
FT DOMAIN 1317..1401
FT /note="CS"
FT REGION 292..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 477..505
FT /note="Q motif"
FT MOTIF 642..645
FT /note="DEAD box"
FT COMPBIAS 297..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 521..528
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1476 AA; 168480 MW; 94341F7A3C1103CB CRC64;
MEHQLDPDQE ESILITHFVN PHQFSYVRCI DVENSAMLVR QIEQDLKDYC SSERTKQVYV
EDERVIVRYQ RWSPPKLVRG VVRRRQNEEY LVWILDYGFN LCCSVWDLWP LPDHLSRSLC
DFKEGGVALI APHSGSVWSR SAIESLDKQL EDANQLTFQV VHRGKSNRNF GLLKFRSSCQ
TEDAANFLIK QDQGRCKETL TMAIPYEDIS FEKAEINDMA IDTRPRLRRI LELVVLLSEN
AKESTPTPSA IQQKKLDALL QSHETYLIPN SVKLLSKVQS ISESSMQTAL ANRSKQISKE
LPHKANQSED NRKKEVKYLE SENLSECLSK VKLSSYQQKN TDSSTLSGPR NLASSSTNSN
SNVRKSMTLF KSSGAHLTTS LSVPLTENCT NQSNNRTVVF SMDKMEQIFN DMLGKNPSER
SVQKNRSQMP NSNVSTTKRC VEKMHVCRSE NMGDRKPSVC LKHLVLAHSP EPVNPVTSYK
ELPLGNTILN AMDDLNFQTP LPTQIYAWPH LVNRGSLVLV NPSGTGRSWS YLPVICSSVL
SSFENVTSNL DTRIAPGPLA ILIVDSVENA KKLASHCEFL MKDFNTQNLK VVNTHAHSMM
DVYMMLLNSC GVLVTTLAHL NNILSNELPL VNPTRLEFII FDDYDRKRLD NAELLKEVFQ
KVNSIGGLSK QLVLVAQQWH SERFQKLLNR TTKPLILFGD FLEAALYGGL KFNVTLRSSA
LKARQLLDIL AEQDGSKKRT LIYCKNQMEL EELSAILIEA GLQCVDISKA QNQSPNRLML
VDDSQVRKQL PVRNIQLLIH FSLPESWLRF SRRFHTMADN IRNLFTKPIG RGQDLITYIL
MDENNAKEWP RIMKFLQDHG LTTQSMPDSE QQLDNTLPYC PYKLSNGNCN RNQCNKRHHF
LKTDLPKIGN PLLQPGTLIR CKFLKAYDPA HMAVMPMKYK SKDSTIWIDV PYPSYPSTLV
FKMSFGVPRK VHNPCKINDV CFVQHKELLS RVRIVDNPAR PQVTVQLMDY GTELLQVKAS
QLLECPEQFR DLQQLAMDIR LSGLAGSGQG GMWSTDSIQW VQDRFADINE EIMQITVDFG
VLDVAYVKEI ALIEECPTML TSVYKTFLRK ELLRQGFAKI DSTSILELRA IHEQWKQEME
ELRANKENIV CSSTDLDNRD SKITSLQNKQ ATCSSGKEED LNPVETPLII ASPNSNETLE
ERKHVSDKVQ NKIDELNDFN KSVEIEHVQD ASPLDSSTAL INTLIHELNT KSPTKKKNTQ
EFIKNIVHED ETQSIHHEIS SSTNSLKQDK TIVVGPQDPP KELFLQYLNC ATKSRESVYP
MVKWHQTLTH IELVVEQQML EYKLGLDGNT LEYKVNETTP PQRFILNLLG EVRIDSVKQH
GYYLHIKLTK VGLLFHWPTL LNSLYVQKHA HWLIYDSERS HGPPPSFGLV LWEGYLTHKK
TKSYSDSESS EFSSTPEDFI EPGVEYCEMD SNLYED