SO_DROME
ID SO_DROME Reviewed; 416 AA.
AC Q27350; A0AVT8; Q9V4L0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Protein sine oculis;
GN Name=so; ORFNames=CG11121;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC TISSUE=Head;
RX PubMed=7896096; DOI=10.1093/genetics/138.4.1137;
RA Serikaku M.A., O'Tousa J.E.;
RT "Sine oculis is a homeobox gene required for Drosophila visual system
RT development.";
RL Genetics 138:1137-1150(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC TISSUE=Embryo, and Eye imaginal disk;
RX PubMed=7910468; DOI=10.1016/0896-6273(94)90308-5;
RA Cheyette B.N.R., Green P.J., Martin K., Garren H., Hartenstein V.,
RA Zipursky S.L.;
RT "The Drosophila sine oculis locus encodes a homeodomain-containing protein
RT required for the development of the entire visual system.";
RL Neuron 12:977-996(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for visual system development. May transcriptionally
CC regulate genes necessary for optic lobe invagination and Bolwig's nerve
CC formation. {ECO:0000269|PubMed:7896096, ECO:0000269|PubMed:7910468}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:7910468}.
CC -!- TISSUE SPECIFICITY: In developing embryos, expressed in the eye disk
CC epithelium, bolwig's organ and the optic lobe primordium at areas of
CC invagination. In adults, present in photoreceptor cells in the apical
CC regions of the retina, and in optic lobes.
CC {ECO:0000269|PubMed:7910468}.
CC -!- DEVELOPMENTAL STAGE: In the eye imaginal disk, first expressed at the
CC onset of the third instar and continues throughout this stage.
CC Expression in the optic lobe primordium begins at stage 5 and
CC disappears when invagination is completed (stage 12). Further
CC expression is noted in optic lobe ganglia in late third instar.
CC {ECO:0000269|PubMed:7910468}.
CC -!- DISRUPTION PHENOTYPE: Flies specifically display visual defects. These
CC range from reduced ocelli and ommatidia number in weak loss-of-function
CC phenotypes to complete absence of compound eyes and bolwig's organ in
CC more severe lethal phenotypes. {ECO:0000269|PubMed:7896096,
CC ECO:0000269|PubMed:7910468}.
CC -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC {ECO:0000305}.
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DR EMBL; S77459; AAB34685.1; -; mRNA.
DR EMBL; L31626; AAA21800.1; -; mRNA.
DR EMBL; AE013599; AAF59260.1; -; Genomic_DNA.
DR EMBL; BT029256; ABK30893.1; -; mRNA.
DR PIR; S50342; S50342.
DR RefSeq; NP_476733.1; NM_057385.5.
DR AlphaFoldDB; Q27350; -.
DR SMR; Q27350; -.
DR BioGRID; 61542; 40.
DR DIP; DIP-18228N; -.
DR IntAct; Q27350; 10.
DR STRING; 7227.FBpp0089177; -.
DR PaxDb; Q27350; -.
DR EnsemblMetazoa; FBtr0088970; FBpp0089177; FBgn0003460.
DR GeneID; 35662; -.
DR KEGG; dme:Dmel_CG11121; -.
DR CTD; 35662; -.
DR FlyBase; FBgn0003460; so.
DR VEuPathDB; VectorBase:FBgn0003460; -.
DR eggNOG; KOG0775; Eukaryota.
DR HOGENOM; CLU_046914_5_1_1; -.
DR InParanoid; Q27350; -.
DR OMA; PNNNGLH; -.
DR OrthoDB; 1040044at2759; -.
DR PhylomeDB; Q27350; -.
DR SignaLink; Q27350; -.
DR BioGRID-ORCS; 35662; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 35662; -.
DR PRO; PR:Q27350; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0003460; Expressed in eye disc (Drosophila) and 46 other tissues.
DR ExpressionAtlas; Q27350; baseline and differential.
DR Genevisible; Q27350; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0008134; F:transcription factor binding; IPI:FlyBase.
DR GO; GO:0001746; P:Bolwig's organ morphogenesis; IMP:FlyBase.
DR GO; GO:0007623; P:circadian rhythm; IGI:FlyBase.
DR GO; GO:0048749; P:compound eye development; IMP:FlyBase.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0009649; P:entrainment of circadian clock; IMP:FlyBase.
DR GO; GO:0008347; P:glial cell migration; IMP:FlyBase.
DR GO; GO:0001744; P:insect visual primordium formation; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035271; P:ring gland development; IMP:FlyBase.
DR GO; GO:0007283; P:spermatogenesis; IMP:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..416
FT /note="Protein sine oculis"
FT /id="PRO_0000049315"
FT DNA_BIND 218..277
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 32..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 45025 MW; 669E4BD95B857996 CRC64;
MLQHPATDFY DLAAANAAAV LTARHTPPYS PTGLSGSVAL HNNNNNNSST SNNNNSTLDI
MAHNGGGAGG GLHLNSSSNG GGGGGVVSGG GSGGRENLPS FGFTQEQVAC VCEVLQQAGN
IERLGRFLWS LPQCDKLQLN ESVLKAKAVV AFHRGQYKEL YRLLEHHHFS AQNHAKLQAL
WLKAHYVEAE KLRGRPLGAV GKYRVRRKFP LPRTIWDGEE TSYCFKEKSR SVLRDWYSHN
PYPSPREKRD LAEATGLTTT QVSNWFKNRR QRDRAAEHKD GSTDKQHLDS SSDSEMEGSM
LPSQSAQHQQ QQQQQQHSPG NSSGNNNGLH QQQLQHVAAE QGLQHHPHQP HPASNIANVA
ATKSSGGGGG GGVSAAAAAQ MQMPPLTAAV AYSHLHSVMG AMPMTAMYDM GEYQHL