ID   SP110_VANPO             Reviewed;         929 AA.
AC   A7THU9;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Spindle pole body component 110;
DE   AltName: Full=Spindle pole body spacer protein SPC110;
GN   Name=SPC110; ORFNames=Kpol_1031p15;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for the
CC       proper execution of spindle pole body (SPB) duplication. Potential role
CC       in cross-linking filaments or anchoring other molecules. It is
CC       essential for growth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       microtubule organizing center, spindle pole body {ECO:0000250}.
CC       Note=Tightly associated with the nucleus. It is present in a granular
CC       pattern that excludes the nucleolus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPC110 family. {ECO:0000305}.
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DR   EMBL; DS480393; EDO18111.1; -; Genomic_DNA.
DR   RefSeq; XP_001645969.1; XM_001645919.1.
DR   AlphaFoldDB; A7THU9; -.
DR   SMR; A7THU9; -.
DR   STRING; 436907.A7THU9; -.
DR   EnsemblFungi; EDO18111; EDO18111; Kpol_1031p15.
DR   GeneID; 5546381; -.
DR   KEGG; vpo:Kpol_1031p15; -.
DR   eggNOG; ENOG502QUTQ; Eukaryota.
DR   HOGENOM; CLU_329279_0_0_1; -.
DR   InParanoid; A7THU9; -.
DR   OMA; EISMYQE; -.
DR   OrthoDB; 1115170at2759; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040593; Spc110_C.
DR   Pfam; PF18520; Spc110_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..929
FT                   /note="Spindle pole body component 110"
FT                   /id="PRO_0000409202"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          117..777
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  109782 MW;  5BC31EC36FD3A320 CRC64;
     MDHTGEQNIQ SVKSYEFTPI GYIKEKQNNG ASKRPNESPI KESMQDTFRN ESPPRKVRRT
     SIDDAMNSRM FNDSMQFDDT LPELDVNLQS SKLTSINMNK KNLIKELKEN SNASNPLKEQ
     QEQLSKLTTE NYNLKLKCNS LLKVLNNVTD QGELRKSLEF LDEIEEWKSK YSTANSEFNL
     LKIKYDDLVI KFRNLESKVD EQESEVEDHT RCIIERDNLQ NKIDKLSEEL GTLNDKLDTI
     TKELIAKDEL IASNEEDIKQ LNSHIDTLKN TIRGLEETII EKDDNLKKQK DEIKTLNNNL
     NDSDHLGSEF LLLQNKLKEK NSQISVLENN LIDSKNTATE LKTRLENLQK EYDDKLREKI
     NQIHKLDDNI KQLKSERDSK YVSLDTNDKV RKDFERMREN NANLDSKLSQ ISNENKLFRD
     KISKLSNQLD DTKRERDNQV ELMKRRIDEI ITNNNRENSI AADKSEEIRE KQEAHINELQ
     RKLNDTLKVQ TLSISTVEDK FKAEILKTKK ELEENAQKLQ KSEELVKELK RQVIENTTNA
     SERNSKRLET KDKEINLLKN DIIELKNKIN SLEKDSKLED NNLREYYTNK IRQIEEESLN
     EKVKLEREIF MLKSERDTLI ESNKHDINFW KSKCNSLEKQ NEALLSQENE GFSSVNLKLN
     QRLKELDELL NQNNTLKKDN MELTRKLSKS QILNEEYKVE LRKAVADLDM ATKEYQKSKD
     FTKIRGSDDS NFELDNMRKN LLIMKTKYNN IKKDYLTKLS ELQEENLQLE KKLSMNQPTS
     RSSDNAAAVQ QDRIDYYRLK YHNEVKSNND LKVMNEYLNR VLMAGSQQIR LDLLKLKEEM
     NLNDYNYSNF PNRDYYNSRN PYESAYDFRF VNNSHNIFEN RHRKKFKTIA LLVKACVRMK
     NTAIKRRWDE QRINYLQRKI AVDDNRITW