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SP13A_XENLA
ID   SP13A_XENLA             Reviewed;        1008 AA.
AC   Q6DDH6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Histone deacetylase complex subunit SAP130-A;
DE   AltName: Full=130 kDa Sin3-associated polypeptide A;
DE   AltName: Full=Sin3-associated polypeptide p130 A;
GN   Name=sap130-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAP130 family. {ECO:0000305}.
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DR   EMBL; BC077587; AAH77587.1; -; mRNA.
DR   RefSeq; NP_001086872.1; NM_001093403.1.
DR   AlphaFoldDB; Q6DDH6; -.
DR   SMR; Q6DDH6; -.
DR   DNASU; 446707; -.
DR   GeneID; 446707; -.
DR   KEGG; xla:446707; -.
DR   CTD; 446707; -.
DR   Xenbase; XB-GENE-6083649; sap130.S.
DR   OrthoDB; 242848at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 446707; Expressed in testis and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR024137; His_deAcase_cplx_SAP130.
DR   InterPro; IPR031963; SAP130_C.
DR   PANTHER; PTHR13497; PTHR13497; 1.
DR   Pfam; PF16014; SAP130_C; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1008
FT                   /note="Histone deacetylase complex subunit SAP130-A"
FT                   /id="PRO_0000283739"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..643
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1008 AA;  106706 MW;  91855A6560DFFC06 CRC64;
     MNSQQFPRQA ASMPSPQVSN SGASVGQNVQ GQGDEVARDM DVQSRDLLGA GTVLPSRDDK
     QEPVVVRPYP QVQMFTSHHP LQPAPSLTMT AQPAHLTSAV PLSFSENILK QTSKSTMPSR
     PIAPAPPSAM SAVPKVSGQG TVTMESGLPQ TSAIPVATIS GQQGHPNSLH HIMAATNVHM
     SIIRSSAPGP PLHIGASHLP RGAAAAAVMS SSKVTTMLRP ASAQIPSAAA AQSATQHIIH
     PPIQSRPPVT TTSLTPAVVA TVSATRAQSP VITTTPAHAA EPVLRPTLSI QQHPPPSAIS
     IQRSAQARDA ATTRITLPTH PALGVQKPQL HAMTQKTLFG TGNPVAAATV APILATNTLP
     SVTTSGSAPH TQVPTSTIVS MTMPTHSSHA TAVTASNIPV AKVVPQQITH TSPRIQSDYG
     TERGNLIPIP GHRASPNPMT MEARSENRQP VPVQLQYFLP TYPPSAYPLA AHTYTPITSS
     VSTIRQYPVS AQAPNSAITA QSVASTVHLN QMQLINMDTS HARHIQGIQP APVSAQGIQQ
     SPFSAQGIQA TPISTQGIQP TQMNTQAIHP ATSITNQGVQ TSSVSSQQAS SEPKASVVLA
     EGATIVANPI NGAFNATPGG TTVMQSHSQS PGIGSSPAQG SSPRPSILRK KPATDGTKPK
     ADLHAAVAPG VTGDPGIADQ PSAAASLPSS HHPAAAVPSP PSQPASGSMP SSIHITPATI
     PALSAPPPLL SNAPSGAVMP EAKVKEEAEP MDISRPVSVP LLPPNSISSP LTVLANNISI
     PVGELLPGAS PRKKPRKQQH VISTEEGDMM ETNSTDEERC HAVKPLTSRP EKRKSPPKEY
     IDEEGVRYVP VRPRPPITLL RHYRNPWKAA YHHFQRYSDV RVKEEKKLTL QEVANQKGIT
     CRVQGWKTHL CAAQLLQLIK LEQDVFERLT VLQEGLVPKK KTATDDDLHR INELIQGNMQ
     RCKLVMDQIT ESRDCMLKVL DHKDRVLKLL NKSGASRRLS KVKQKDKM
 
 
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