SP13A_XENLA
ID SP13A_XENLA Reviewed; 1008 AA.
AC Q6DDH6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Histone deacetylase complex subunit SAP130-A;
DE AltName: Full=130 kDa Sin3-associated polypeptide A;
DE AltName: Full=Sin3-associated polypeptide p130 A;
GN Name=sap130-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SAP130 family. {ECO:0000305}.
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DR EMBL; BC077587; AAH77587.1; -; mRNA.
DR RefSeq; NP_001086872.1; NM_001093403.1.
DR AlphaFoldDB; Q6DDH6; -.
DR SMR; Q6DDH6; -.
DR DNASU; 446707; -.
DR GeneID; 446707; -.
DR KEGG; xla:446707; -.
DR CTD; 446707; -.
DR Xenbase; XB-GENE-6083649; sap130.S.
DR OrthoDB; 242848at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 446707; Expressed in testis and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR024137; His_deAcase_cplx_SAP130.
DR InterPro; IPR031963; SAP130_C.
DR PANTHER; PTHR13497; PTHR13497; 1.
DR Pfam; PF16014; SAP130_C; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1008
FT /note="Histone deacetylase complex subunit SAP130-A"
FT /id="PRO_0000283739"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 106706 MW; 91855A6560DFFC06 CRC64;
MNSQQFPRQA ASMPSPQVSN SGASVGQNVQ GQGDEVARDM DVQSRDLLGA GTVLPSRDDK
QEPVVVRPYP QVQMFTSHHP LQPAPSLTMT AQPAHLTSAV PLSFSENILK QTSKSTMPSR
PIAPAPPSAM SAVPKVSGQG TVTMESGLPQ TSAIPVATIS GQQGHPNSLH HIMAATNVHM
SIIRSSAPGP PLHIGASHLP RGAAAAAVMS SSKVTTMLRP ASAQIPSAAA AQSATQHIIH
PPIQSRPPVT TTSLTPAVVA TVSATRAQSP VITTTPAHAA EPVLRPTLSI QQHPPPSAIS
IQRSAQARDA ATTRITLPTH PALGVQKPQL HAMTQKTLFG TGNPVAAATV APILATNTLP
SVTTSGSAPH TQVPTSTIVS MTMPTHSSHA TAVTASNIPV AKVVPQQITH TSPRIQSDYG
TERGNLIPIP GHRASPNPMT MEARSENRQP VPVQLQYFLP TYPPSAYPLA AHTYTPITSS
VSTIRQYPVS AQAPNSAITA QSVASTVHLN QMQLINMDTS HARHIQGIQP APVSAQGIQQ
SPFSAQGIQA TPISTQGIQP TQMNTQAIHP ATSITNQGVQ TSSVSSQQAS SEPKASVVLA
EGATIVANPI NGAFNATPGG TTVMQSHSQS PGIGSSPAQG SSPRPSILRK KPATDGTKPK
ADLHAAVAPG VTGDPGIADQ PSAAASLPSS HHPAAAVPSP PSQPASGSMP SSIHITPATI
PALSAPPPLL SNAPSGAVMP EAKVKEEAEP MDISRPVSVP LLPPNSISSP LTVLANNISI
PVGELLPGAS PRKKPRKQQH VISTEEGDMM ETNSTDEERC HAVKPLTSRP EKRKSPPKEY
IDEEGVRYVP VRPRPPITLL RHYRNPWKAA YHHFQRYSDV RVKEEKKLTL QEVANQKGIT
CRVQGWKTHL CAAQLLQLIK LEQDVFERLT VLQEGLVPKK KTATDDDLHR INELIQGNMQ
RCKLVMDQIT ESRDCMLKVL DHKDRVLKLL NKSGASRRLS KVKQKDKM