ID   SP17_MACFA              Reviewed;         151 AA.
AC   O19021;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Sperm surface protein Sp17;
DE   AltName: Full=Sperm autoantigenic protein 17;
GN   Name=SPA17; Synonyms=SP17;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=9510968; DOI=10.1095/biolreprod58.3.794;
RA   Lea I.A., Kurth B., O'Rand M.G.;
RT   "Immune response to immunization with sperm antigens in the macaque
RT   oviduct.";
RL   Biol. Reprod. 58:794-800(1998).
CC   -!- FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind
CC       spermatozoa to the zona pellucida with high affinity. Might function in
CC       binding zona pellucida and carbohydrates (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. May interact with ROPN1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Testis- and sperm-specific.
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DR   EMBL; AF005551; AAB62888.1; -; mRNA.
DR   AlphaFoldDB; O19021; -.
DR   SMR; O19021; -.
DR   STRING; 9541.XP_005580088.1; -.
DR   eggNOG; ENOG502S4R6; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:InterPro.
DR   InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR012105; Sp17.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF02197; RIIa; 1.
DR   PIRSF; PIRSF016533; Sp17; 1.
DR   SMART; SM00015; IQ; 1.
DR   SMART; SM00394; RIIa; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome.
FT   CHAIN           1..151
FT                   /note="Sperm surface protein Sp17"
FT                   /id="PRO_0000181342"
FT   DOMAIN          114..143
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          68..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   151 AA;  17401 MW;  E681586AB713F03C CRC64;
     MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR EKTNFDPAEW
     GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QIPGKEEEAS VTILDSSEED KEKEEVAAVK
     IQAAFRGHVA REEVKKMKTD SLQNEEKEEN K