SP17_MOUSE
ID SP17_MOUSE Reviewed; 149 AA.
AC Q62252;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Sperm surface protein Sp17;
DE AltName: Full=Sperm autoantigenic protein 17;
GN Name=Spa17; Synonyms=Sp17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Testis;
RX PubMed=7578682; DOI=10.1095/biolreprod53.3.579;
RA Kong M., Richardson R.T., Widgren E.E., O'Rand M.G.;
RT "Sequence and localization of the mouse sperm autoantigenic protein,
RT Sp17.";
RL Biol. Reprod. 53:579-590(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind
CC spermatozoa to the zona pellucida with high affinity. Might function in
CC binding zona pellucida and carbohydrates (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. May interact with ROPN1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Testis- and sperm-specific.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z46299; CAA86455.1; -; mRNA.
DR EMBL; BC059727; AAH59727.1; -; mRNA.
DR CCDS; CCDS22982.1; -.
DR PIR; S49527; S49527.
DR RefSeq; NP_001311474.1; NM_001324545.1.
DR RefSeq; NP_035579.1; NM_011449.2.
DR AlphaFoldDB; Q62252; -.
DR SMR; Q62252; -.
DR STRING; 10090.ENSMUSP00000002013; -.
DR iPTMnet; Q62252; -.
DR PhosphoSitePlus; Q62252; -.
DR REPRODUCTION-2DPAGE; Q62252; -.
DR MaxQB; Q62252; -.
DR PaxDb; Q62252; -.
DR PRIDE; Q62252; -.
DR ProteomicsDB; 257289; -.
DR Antibodypedia; 32898; 275 antibodies from 26 providers.
DR DNASU; 20686; -.
DR Ensembl; ENSMUST00000002013; ENSMUSP00000002013; ENSMUSG00000001948.
DR GeneID; 20686; -.
DR KEGG; mmu:20686; -.
DR UCSC; uc009ovd.2; mouse.
DR CTD; 53340; -.
DR MGI; MGI:1333778; Spa17.
DR VEuPathDB; HostDB:ENSMUSG00000001948; -.
DR eggNOG; ENOG502S4R6; Eukaryota.
DR GeneTree; ENSGT00440000039164; -.
DR HOGENOM; CLU_115900_0_0_1; -.
DR InParanoid; Q62252; -.
DR OMA; NCESEKE; -.
DR OrthoDB; 1255894at2759; -.
DR PhylomeDB; Q62252; -.
DR TreeFam; TF332959; -.
DR BioGRID-ORCS; 20686; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Spa17; mouse.
DR PRO; PR:Q62252; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q62252; protein.
DR Bgee; ENSMUSG00000001948; Expressed in seminiferous tubule of testis and 187 other tissues.
DR ExpressionAtlas; Q62252; baseline and differential.
DR Genevisible; Q62252; MM.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0031514; C:motile cilium; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; IDA:MGI.
DR GO; GO:0035686; C:sperm fibrous sheath; IDA:MGI.
DR GO; GO:0097228; C:sperm principal piece; IDA:MGI.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; TAS:MGI.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR012105; Sp17.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF02197; RIIa; 1.
DR PIRSF; PIRSF016533; Sp17; 1.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00394; RIIa; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome.
FT CHAIN 1..149
FT /note="Sperm surface protein Sp17"
FT /id="PRO_0000181344"
FT DOMAIN 112..141
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 83..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 149 AA; 17296 MW; C7E05D111D6AF0DC CRC64;
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFENLLEKR EKTSFDPAEW
GAKVEDRFYN NHAFKEQEQV EKCEQELAKS SGREETPVTP FEESTEEERE QEEAAALKIQ
SLFRGHVARE EVKKMKSDKN ENLKEEADN
