ID   SP17_RABIT              Reviewed;         146 AA.
AC   P36425;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Sperm surface protein Sp17;
DE   AltName: Full=Sperm autoantigenic protein 17;
GN   Name=SPA17; Synonyms=SP17;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 113-126.
RC   STRAIN=New Zealand white; TISSUE=Testis;
RX   PubMed=7525387; DOI=10.1006/dbio.1994.1285;
RA   Richardson R.T., Yamasaki N., O'Rand M.G.;
RT   "Sequence of a rabbit sperm zona pellucida binding protein and localization
RT   during the acrosome reaction.";
RL   Dev. Biol. 165:688-701(1994).
CC   -!- FUNCTION: Sperm surface zona pellucida binding protein. Helps to bind
CC       spermatozoa to the zona pellucida with high affinity. Might function in
CC       binding zona pellucida and carbohydrates.
CC   -!- SUBUNIT: Homodimer. May interact with ROPN1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Testis- and sperm-specific.
CC   -!- PTM: The N-terminus is blocked.
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DR   EMBL; Z20655; CAA79674.1; -; mRNA.
DR   PIR; I46506; I46506.
DR   RefSeq; NP_001076095.1; NM_001082626.1.
DR   AlphaFoldDB; P36425; -.
DR   SMR; P36425; -.
DR   STRING; 9986.ENSOCUP00000002646; -.
DR   Ensembl; ENSOCUT00000003042; ENSOCUP00000002646; ENSOCUG00000003044.
DR   GeneID; 100009312; -.
DR   KEGG; ocu:100009312; -.
DR   CTD; 53340; -.
DR   eggNOG; ENOG502S4R6; Eukaryota.
DR   GeneTree; ENSGT00440000039164; -.
DR   HOGENOM; CLU_115900_0_0_1; -.
DR   InParanoid; P36425; -.
DR   OMA; NCESEKE; -.
DR   OrthoDB; 1255894at2759; -.
DR   TreeFam; TF332959; -.
DR   Proteomes; UP000001811; Chromosome 1.
DR   Bgee; ENSOCUG00000003044; Expressed in testis and 16 other tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IDA:GO_Central.
DR   GO; GO:0007339; P:binding of sperm to zona pellucida; IDA:GO_Central.
DR   InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR012105; Sp17.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF02197; RIIa; 1.
DR   PIRSF; PIRSF016533; Sp17; 1.
DR   SMART; SM00015; IQ; 1.
DR   SMART; SM00394; RIIa; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Reference proteome.
FT   CHAIN           1..146
FT                   /note="Sperm surface protein Sp17"
FT                   /id="PRO_0000181346"
FT   DOMAIN          110..139
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          76..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   146 AA;  16892 MW;  3FF302B883D9566F CRC64;
     MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFENLLEKR EKTNFDPAEW
     GAKVDDRFYN NHAFQEHESE KCEAEEKSQS VTEEETPVLT IDSEDDKDKE EMAALKIQAA
     FRGHLAREDV KKIRTNKAEE ETEENN