SP201_HUMAN
ID SP201_HUMAN Reviewed; 823 AA.
AC Q3ZLR7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Transcription factor SPT20 homolog-like 1;
GN Name=SUPT20HL1; Synonyms=FAM48B1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 245-318.
RC TISSUE=Testis;
RA Wang P.J., Skaletsky H., Page D.C.;
RT "Retroposition dynamics of the human X chromosome.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SPT20 family. {ECO:0000305}.
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DR EMBL; AC004552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY736017; AAW59547.1; -; mRNA.
DR AlphaFoldDB; Q3ZLR7; -.
DR SMR; Q3ZLR7; -.
DR IntAct; Q3ZLR7; 2.
DR iPTMnet; Q3ZLR7; -.
DR PhosphoSitePlus; Q3ZLR7; -.
DR BioMuta; HGNC:30773; -.
DR DMDM; 205831478; -.
DR MassIVE; Q3ZLR7; -.
DR PeptideAtlas; Q3ZLR7; -.
DR PRIDE; Q3ZLR7; -.
DR GeneCards; SUPT20HL1; -.
DR HGNC; HGNC:30773; SUPT20HL1.
DR neXtProt; NX_Q3ZLR7; -.
DR InParanoid; Q3ZLR7; -.
DR PhylomeDB; Q3ZLR7; -.
DR Pharos; Q3ZLR7; Tdark.
DR PRO; PR:Q3ZLR7; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q3ZLR7; protein.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR021950; Spt20.
DR PANTHER; PTHR13526; PTHR13526; 1.
DR Pfam; PF12090; Spt20; 2.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..823
FT /note="Transcription factor SPT20 homolog-like 1"
FT /id="PRO_0000344459"
FT REGION 246..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 89431 MW; 767D015784918F10 CRC64;
MDRDLEQALD RAENIIEIAQ QRPPRRRYSP RAGKTLQEKL YDIYVEECGK EPEDPQELRS
NVNLLEKLVR RESLPCLLVN LYPGNQGYSV MLQREDGSFA ETIRLPYEER ALLDYLDAEE
LPPALGDVLD KASVNIFHSG CVIVEVRDYR QSSNMQPPGY QSRHILLRPT MQTLAHDVKM
MTRDGQKWSQ EDKLQLESQL ILATAEPLCL DPSVAVACTA NRLLYNKQKM NTDPMKRCLQ
RYSWPSVKPQ QEQSDCPPPP ELRVSTSGQK EERKVGQPCE LNIAKAGSCV DTWKGRPCDL
AVPSEVDVEK LAKGYQSVTA ADPQLPVWPA QEVEDPFGFA LEAGCQAWDT KPSIMQSFND
PLLCGKIRPR KKARQKSQKS PWQPFPDDHS ACLRPGSETD AGRAVSQAQE SVQSKVKGPG
KMSHSSSGPA SVSQLSSWKT PEQPDPVWVQ SSVSGKGEKH PPPRTQLPSS SGKISSGNSF
PPQQAGSPLK PAAPAAAASA APSHSQKPSV PLIQASRPCP AAQPPTKFIK IAPAIQLRTG
STGLKAINVE GPVQGAQALG SSFKPVQAPG SGAPAPAGIS GSDLQSSGGP LPDARPGAVQ
ASSPAPLQFF LNTPEGLRPL TLLQVPQGSA VLTGPQQQSH QLVSLQQLQQ PTAAHPPQPG
PQGSALGLST QGQAFPAQQL LKVNPTRARS GLQPQPQPAV LSLLGSAQVP QQGVQLPSVL
RQQQPQPQPP KLQLQPQWQP KPRQEQPQSQ QQQPQHIQLQ TQQLRVLQQP QHIQLQTQQL
RVLQQPVFLA TGAVQIVQPH PGVQVGSQLV DQRKEGKPTP PAP
