SP202_HUMAN
ID SP202_HUMAN Reviewed; 817 AA.
AC P0C7V6;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Putative transcription factor SPT20 homolog-like 2;
GN Name=SUPT20HL2; Synonyms=FAM48B2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the SPT20 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC096509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001129705.1; NM_001136233.1.
DR AlphaFoldDB; P0C7V6; -.
DR SMR; P0C7V6; -.
DR IntAct; P0C7V6; 1.
DR iPTMnet; P0C7V6; -.
DR PhosphoSitePlus; P0C7V6; -.
DR BioMuta; HGNC:31797; -.
DR DMDM; 206557847; -.
DR MassIVE; P0C7V6; -.
DR PeptideAtlas; P0C7V6; -.
DR PRIDE; P0C7V6; -.
DR ProteomicsDB; 52376; -.
DR DNASU; 170067; -.
DR Ensembl; ENST00000486479.3; ENSP00000503941.1; ENSG00000223611.7.
DR GeneID; 170067; -.
DR KEGG; hsa:170067; -.
DR MANE-Select; ENST00000486479.3; ENSP00000503941.1; NM_001136233.3; NP_001129705.3.
DR CTD; 170067; -.
DR GeneCards; SUPT20HL2; -.
DR HGNC; HGNC:31797; SUPT20HL2.
DR HPA; ENSG00000223611; Not detected.
DR neXtProt; NX_P0C7V6; -.
DR PharmGKB; PA134896852; -.
DR VEuPathDB; HostDB:ENSG00000223611; -.
DR GeneTree; ENSGT00390000013549; -.
DR InParanoid; P0C7V6; -.
DR OMA; EVNTMTR; -.
DR OrthoDB; 407128at2759; -.
DR PhylomeDB; P0C7V6; -.
DR PathwayCommons; P0C7V6; -.
DR BioGRID-ORCS; 170067; 8 hits in 186 CRISPR screens.
DR GenomeRNAi; 170067; -.
DR Pharos; P0C7V6; Tdark.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P0C7V6; protein.
DR Bgee; ENSG00000223611; Expressed in left uterine tube and 19 other tissues.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR021950; Spt20.
DR PANTHER; PTHR13526; PTHR13526; 1.
DR Pfam; PF12090; Spt20; 2.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..817
FT /note="Putative transcription factor SPT20 homolog-like 2"
FT /id="PRO_0000344460"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 87541 MW; 5868B02A4228637C CRC64;
MDRDLEQALD RTENITEIAQ QRRPRRRYSP RAGKTLQEKL YDIYVEECGK EPEDPQELRS
NVNLLEKLVR RESLPCLLVN LYPGNQGYSV MLQREDGSFA ETIRLPYEER ALLDYLDAEE
LPPALGDVLD KASVNIFHSG CVIVEVRDYR QSSNMQPPGY QSRHILLRPT MQTLAPEVKT
MTRDGEKWSQ EDKFPLESQL ILATAEPLCL DPSVAVACTA NRLLYNKQKM NTDPMEQCLQ
RYSWPSVKPQ QEQSDCPPPP ELRVSTSGQK EERKVGQPCE LNITKAGSCV DTWKGRPCDL
AVPSEVDVEK LAKGYQSVTA ADPQLPVWPA QEVEDPFRHA WEAGCQAWDT KPNIMQSFND
PLLCGKIRPR KKARQKSQKS PWQPFPDDHS ACLRPGSETD AGRAVSQAQE SVQSKVKGPG
KMSHSSSGPA SVSQLSSWKT PEQPDPVWVQ SSVSGKGEKH PPPRTQLPSS SGKISSGNSF
PPQQAGSPLK RPFPAAAPAV AAAAPAPAPA PAAAPALAAA AVAAAAGGAA PSHSQKPSVP
LIKASRRRPA AGRPTRFVKI APAIQVRTGS TGLKATNVEG PVRGAQVLGC SFKPVQAPGS
GAPAPAGISG SGLQSSGGPL PDARPGAVQA SSPAPLQFFL NTPEGLRPLT LQVPQGWAVL
TGPQQQSHQL VSLQQLQQPT AAHPPQPGPQ GSTLGLSTQG QAFPAQQLLN VNLTGAGSGL
QPQPQAAVLS LLGSAQVPQQ GVQLPFVLGQ QPQPLLLLQP QPQPQQIQLQ TQPLRVLQQP
VFLATGAVQI VQPHPGVQAG SQLVGQRKGG KPTPPAP
