ID   SP20H_PONAB             Reviewed;         522 AA.
AC   Q5R724;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Transcription factor SPT20 homolog;
GN   Name=SUPT20H; Synonyms=FAM48A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or
CC       MAPK14) activation during gastrulation. Required for down-regulation of
CC       E-cadherin during gastrulation by regulating E-cadherin protein level
CC       downstream from NCK-interacting kinase (NIK) and independently of the
CC       regulation of transcription by FGF signaling and Snail. Required for
CC       starvation-induced ATG9A trafficking during autophagy (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ATG9A. Interacts with MAPK14 (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT20 family. {ECO:0000305}.
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DR   EMBL; CR860298; CAH92436.1; -; mRNA.
DR   RefSeq; NP_001128975.1; NM_001135503.1.
DR   AlphaFoldDB; Q5R724; -.
DR   SMR; Q5R724; -.
DR   STRING; 9601.ENSPPYP00000006026; -.
DR   PRIDE; Q5R724; -.
DR   GeneID; 100190815; -.
DR   KEGG; pon:100190815; -.
DR   CTD; 55578; -.
DR   eggNOG; ENOG502QS30; Eukaryota.
DR   InParanoid; Q5R724; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   InterPro; IPR021950; Spt20.
DR   PANTHER; PTHR13526; PTHR13526; 1.
DR   Pfam; PF12090; Spt20; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Gastrulation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..522
FT                   /note="Transcription factor SPT20 homolog"
FT                   /id="PRO_0000187041"
FT   REGION          361..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..481
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..522
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         284
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TT00"
FT   MOD_RES         482
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEM7"
FT   MOD_RES         507
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEM7"
FT   MOD_RES         512
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TT00"
SQ   SEQUENCE   522 AA;  58850 MW;  362DF1EA1365DF70 CRC64;
     MYIIESARQR PPKRKYLSSG RKSVFQKLYD LYIEECEKEP EVKKLRRNVN LLEKLVMQET
     LSCLVVNLYP GNEGYSLMLR GKNGSDSETI RLPYEEGELL EYLDAEELPP ILVDLLEKSQ
     VNIFHCGCVI AEIRDYRQSS NMKSPGYQSR HILLRPTMQT LICDVHSITS DNHKWTQEDK
     LLLESQLILA TAEPLCLDPS IAVTCTANRL LYNKQKMNTR PMKRCFKRYS RSSLNRQQDL
     SHCPPPPQLR LLDFLQKRKE RKAGQHYDLK ISKAGNCVDM WKRSPCNLAI PSEVDVEKYA
     KVEKSIKSDD SQPTVWPAHD VKDDYVFECE ASTQYQKTKL TILQSLGDPL YYGKIQPCKA
     DEESDSQMSP SHSSTDDHSN WFIIGSKTDA ERVVNQYQEL VQNEAKCPVK MSHSSSGSAS
     LSQVSPGKET EQTETVSVQS SVLGKGVKHR PPPIKLPSSS GNSSSGNYFS PQQTSSFLKS
     PTPPPSSKPP TIPRKSSVDL NQVSMLSPAA LSPASSSQRH ES