ID   SP20H_RAT               Reviewed;         530 AA.
AC   Q66HC7;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transcription factor SPT20 homolog;
GN   Name=Supt20h; Synonyms=Fam48a, Supt20;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or
CC       MAPK14) activation during gastrulation. Required for down-regulation of
CC       E-cadherin during gastrulation by regulating E-cadherin protein level
CC       downstream from NCK-interacting kinase (NIK) and independently of the
CC       regulation of transcription by FGF signaling and Snail. Required for
CC       starvation-induced ATG9A trafficking during autophagy (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ATG9A. Interacts with MAPK14 (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT20 family. {ECO:0000305}.
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DR   EMBL; BC081923; AAH81923.1; -; mRNA.
DR   RefSeq; NP_001014192.1; NM_001014170.1.
DR   AlphaFoldDB; Q66HC7; -.
DR   SMR; Q66HC7; -.
DR   STRING; 10116.ENSRNOP00000054835; -.
DR   PaxDb; Q66HC7; -.
DR   GeneID; 361946; -.
DR   KEGG; rno:361946; -.
DR   UCSC; RGD:1307812; rat.
DR   CTD; 55578; -.
DR   RGD; 1307812; Supt20h.
DR   eggNOG; ENOG502QS30; Eukaryota.
DR   InParanoid; Q66HC7; -.
DR   OrthoDB; 369747at2759; -.
DR   PhylomeDB; Q66HC7; -.
DR   PRO; PR:Q66HC7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR   GO; GO:0070461; C:SAGA-type complex; ISO:RGD.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0035521; P:monoubiquitinated histone deubiquitination; ISO:RGD.
DR   GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; ISO:RGD.
DR   GO; GO:0045722; P:positive regulation of gluconeogenesis; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR021950; Spt20.
DR   PANTHER; PTHR13526; PTHR13526; 1.
DR   Pfam; PF12090; Spt20; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Gastrulation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..530
FT                   /note="Transcription factor SPT20 homolog"
FT                   /id="PRO_0000187042"
FT   REGION          419..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..486
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..530
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         296
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TT00"
FT   MOD_RES         490
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEM7"
FT   MOD_RES         515
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEM7"
FT   MOD_RES         520
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7TT00"
SQ   SEQUENCE   530 AA;  59513 MW;  915393E5E0EE5072 CRC64;
     MQQALEQALD RAEYIVESAQ QRPPKRKCLS SGRKSIFQKL YDLYVEECEK EPEVKKLRRN
     VNLLEKLVMQ ETLSCLVVNL YPGNEGYSLM LRGKNGSDSE TIRLPYEEGE LLEYLDAEEL
     PPILVDLLEK SQVNIFHCGC VIAEIRDYRQ SSNMKSPGYQ SRHILLRPTM QTLVCDVHSI
     TSDNHKWTQE DKLLLESQLI LATAEPLCLD PSVAVACTAN RLLYNRQKMN TRPMKRCLKR
     YSRSSLNRQQ DLSHCPPPPQ LRLLDFLQKR KERKAGQHYD LKISKAGNCV DMWKRSPCNL
     AVPSEVDVEK YAKVEKSIKS DDSQPTMWPA HDVKDDYVFE CEGGNQYQKT KLTILQSLGD
     PLYYGKIQPW KADEESDSQM SPSHSSADDH SNWFIIGSKT DAERVVNQYQ ELVQNEAKCP
     VKMSHSSSGS ASLNSGEEGE PETSSIQSSV LGKGVKHRPP PIKLPSSSGN SSSGNYFTAQ
     QASSFLKSPT PPPPSSKPSL SRKSSVDLSQ VSMLSPAALS PASSSQRHES