ID   SP2B_BACSU              Reviewed;         332 AA.
AC   P37575;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Stage II sporulation protein B;
GN   Name=spoIIB; OrderedLocusNames=BSU28060;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / PY79;
RX   PubMed=8419299; DOI=10.1128/jb.175.2.528-540.1993;
RA   Margolis P.S., Driks A., Losick R.;
RT   "Sporulation gene spoIIB from Bacillus subtilis.";
RL   J. Bacteriol. 175:528-540(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Involved in endospore development.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Under sporulation control.
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DR   EMBL; L04519; AAB59026.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14766.1; -; Genomic_DNA.
DR   PIR; C40646; C40646.
DR   RefSeq; NP_390684.1; NC_000964.3.
DR   RefSeq; WP_004398782.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P37575; -.
DR   SMR; P37575; -.
DR   STRING; 224308.BSU28060; -.
DR   PaxDb; P37575; -.
DR   PRIDE; P37575; -.
DR   EnsemblBacteria; CAB14766; CAB14766; BSU_28060.
DR   GeneID; 937497; -.
DR   KEGG; bsu:BSU28060; -.
DR   PATRIC; fig|224308.179.peg.3048; -.
DR   eggNOG; ENOG5030CIU; Bacteria.
DR   OMA; EAWGGKE; -.
DR   BioCyc; BSUB:BSU28060-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042834; F:peptidoglycan binding; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.1070; -; 1.
DR   InterPro; IPR007730; SPOR-like_dom.
DR   InterPro; IPR036680; SPOR-like_sf.
DR   Pfam; PF05036; SPOR; 1.
DR   SUPFAM; SSF110997; SSF110997; 1.
DR   PROSITE; PS51724; SPOR; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sporulation; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..332
FT                   /note="Stage II sporulation protein B"
FT                   /id="PRO_0000072056"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          175..250
FT                   /note="SPOR"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         122
FT                   /note="G->D: Loss of function."
SQ   SEQUENCE   332 AA;  35923 MW;  FBE12F83C7569A68 CRC64;
     MKKRKNKKNS KAAEKALKVT INGKEETVYE QETPETEANK SMTFSNWEEK RQAEQEVAAS
     QEHPDEDEFN WDSEEDKVFK EDPKVVPPFQ KKKTKLYAKG KTGAAKPVKR VAATIAFAAV
     IGTGLGLFAL NISGNKEASA PASLEDSLGS QTAKAGDTSA DKQTSGAEKQ AAQTEGTYKT
     YAVQAGKFSN EKGAETLTEQ LTEKGYSAVS LSKDDGYTYV IAGLASEKEV SQQLGQVLID
     SDFEAWGGKE LSLSIESDMT DSFKETAELA AKAILDEDIT KASVEKIEKS LGETKASETG
     EKKAILQALK ELEDPSAEAG WKAQQELLAV VK