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SP2SA_BACAN
ID   SP2SA_BACAN             Reviewed;         248 AA.
AC   Q81QD6; E9QWT4; Q6KSL3;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Stage II sporulation protein SA;
DE   AltName: Full=Killer protein SpoIISA;
DE   AltName: Full=Toxin SpoIISA;
GN   Name=spoIISA; OrderedLocusNames=BA_2490, GBAA_2490;
OS   Bacillus anthracis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames / isolate Porton;
RX   PubMed=12721629; DOI=10.1038/nature01586;
RA   Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA   Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA   Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA   Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA   DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA   Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA   Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA   Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA   White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA   Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT   "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT   related bacteria.";
RL   Nature 423:81-86(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
RN   [3]
RP   FUNCTION AS A TOXIN, AND EXPRESSION IN E.COLI.
RC   STRAIN=Ames / isolate Porton;
RX   PubMed=18096016; DOI=10.1111/j.1574-6968.2007.00984.x;
RA   Florek P., Muchova K., Pavelcikova P., Barak I.;
RT   "Expression of functional Bacillus SpoIISAB toxin-antitoxin modules in
RT   Escherichia coli.";
RL   FEMS Microbiol. Lett. 278:177-184(2008).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in E.coli growth ceases. {ECO:0000269|PubMed:18096016}.
CC   -!- SUBUNIT: Probably forms a complex with SpoIISB in which SpoIISB
CC       neutralizes the toxic activity.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SpoIISA toxin family. {ECO:0000305}.
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DR   EMBL; AE016879; AAP26351.1; -; Genomic_DNA.
DR   EMBL; AE017334; AAT31603.1; -; Genomic_DNA.
DR   RefSeq; NP_844865.1; NC_003997.3.
DR   RefSeq; WP_011053162.1; NZ_VTZL01000002.1.
DR   AlphaFoldDB; Q81QD6; -.
DR   STRING; 260799.BAS2314; -.
DR   DNASU; 1084806; -.
DR   EnsemblBacteria; AAP26351; AAP26351; BA_2490.
DR   EnsemblBacteria; AAT31603; AAT31603; GBAA_2490.
DR   KEGG; ban:BA_2490; -.
DR   KEGG; bar:GBAA_2490; -.
DR   PATRIC; fig|198094.11.peg.2462; -.
DR   eggNOG; ENOG5033N7Q; Bacteria.
DR   HOGENOM; CLU_1127307_0_0_9; -.
DR   Proteomes; UP000000427; Chromosome.
DR   Proteomes; UP000000594; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR025940; SpoIISA_toxin.
DR   Pfam; PF14171; SpoIISA_toxin; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sporulation;
KW   Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT   CHAIN           1..248
FT                   /note="Stage II sporulation protein SA"
FT                   /id="PRO_0000415543"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  28704 MW;  CA9E321F889FE7FC CRC64;
     MSLVISNIRI GLFILAIVFL VLVFFYWRNE ELYEEKKQRI RKTWYGLFIV SVTVYFMIKG
     IDLTLWKNLL MFTAMVIFVD IAFILTPNIS EIWGAKFSDI GKTVQSIKRS LIASKARGEI
     YTTIIQNVNP AVFGTMEWHT EEEYTKSLNA FLDSYGEKIG AKIVVFEAAK ELNTNFRGIR
     SQFSTIIPLE YIEQLNEQRA VQVENVGIIP AKIVSDVFIV IDGKKNNLQD RDFENVYNLT
     IHHSYFSK
 
 
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