SP2SA_BACAN
ID SP2SA_BACAN Reviewed; 248 AA.
AC Q81QD6; E9QWT4; Q6KSL3;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Stage II sporulation protein SA;
DE AltName: Full=Killer protein SpoIISA;
DE AltName: Full=Toxin SpoIISA;
GN Name=spoIISA; OrderedLocusNames=BA_2490, GBAA_2490;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP FUNCTION AS A TOXIN, AND EXPRESSION IN E.COLI.
RC STRAIN=Ames / isolate Porton;
RX PubMed=18096016; DOI=10.1111/j.1574-6968.2007.00984.x;
RA Florek P., Muchova K., Pavelcikova P., Barak I.;
RT "Expression of functional Bacillus SpoIISAB toxin-antitoxin modules in
RT Escherichia coli.";
RL FEMS Microbiol. Lett. 278:177-184(2008).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC Upon expression in E.coli growth ceases. {ECO:0000269|PubMed:18096016}.
CC -!- SUBUNIT: Probably forms a complex with SpoIISB in which SpoIISB
CC neutralizes the toxic activity.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SpoIISA toxin family. {ECO:0000305}.
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DR EMBL; AE016879; AAP26351.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT31603.1; -; Genomic_DNA.
DR RefSeq; NP_844865.1; NC_003997.3.
DR RefSeq; WP_011053162.1; NZ_VTZL01000002.1.
DR AlphaFoldDB; Q81QD6; -.
DR STRING; 260799.BAS2314; -.
DR DNASU; 1084806; -.
DR EnsemblBacteria; AAP26351; AAP26351; BA_2490.
DR EnsemblBacteria; AAT31603; AAT31603; GBAA_2490.
DR KEGG; ban:BA_2490; -.
DR KEGG; bar:GBAA_2490; -.
DR PATRIC; fig|198094.11.peg.2462; -.
DR eggNOG; ENOG5033N7Q; Bacteria.
DR HOGENOM; CLU_1127307_0_0_9; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR025940; SpoIISA_toxin.
DR Pfam; PF14171; SpoIISA_toxin; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sporulation;
KW Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT CHAIN 1..248
FT /note="Stage II sporulation protein SA"
FT /id="PRO_0000415543"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 248 AA; 28704 MW; CA9E321F889FE7FC CRC64;
MSLVISNIRI GLFILAIVFL VLVFFYWRNE ELYEEKKQRI RKTWYGLFIV SVTVYFMIKG
IDLTLWKNLL MFTAMVIFVD IAFILTPNIS EIWGAKFSDI GKTVQSIKRS LIASKARGEI
YTTIIQNVNP AVFGTMEWHT EEEYTKSLNA FLDSYGEKIG AKIVVFEAAK ELNTNFRGIR
SQFSTIIPLE YIEQLNEQRA VQVENVGIIP AKIVSDVFIV IDGKKNNLQD RDFENVYNLT
IHHSYFSK