ID   SP2SB_BACCR             Reviewed;          58 AA.
AC   Q81DD0;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Stage II sporulation protein SB;
DE   AltName: Full=Antidote protein SpoIISB;
DE   AltName: Full=Antitoxin SpoIISB;
GN   Name=spoIISB; OrderedLocusNames=BC_2437;
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
RN   [2]
RP   FUNCTION AS AN ANTITOXIN, AND EXPRESSION IN E.COLI.
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=18096016; DOI=10.1111/j.1574-6968.2007.00984.x;
RA   Florek P., Muchova K., Pavelcikova P., Barak I.;
RT   "Expression of functional Bacillus SpoIISAB toxin-antitoxin modules in
RT   Escherichia coli.";
RL   FEMS Microbiol. Lett. 278:177-184(2008).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Antitoxin that binds toxin SpoIISA and neutralizes its toxic activity.
CC       Upon coexpression with SpoIISA in E.coli normal growth is restored.
CC       {ECO:0000269|PubMed:18096016}.
CC   -!- SUBUNIT: Probably forms a complex with SpoIISA neutralizing its toxic
CC       activity.
CC   -!- SIMILARITY: Belongs to the SpoIISB antitoxin family. {ECO:0000305}.
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DR   EMBL; AE016877; AAP09400.1; -; Genomic_DNA.
DR   RefSeq; NP_832199.1; NC_004722.1.
DR   RefSeq; WP_000852629.1; NZ_CP034551.1.
DR   AlphaFoldDB; Q81DD0; -.
DR   SMR; Q81DD0; -.
DR   EnsemblBacteria; AAP09400; AAP09400; BC_2437.
DR   GeneID; 67507121; -.
DR   KEGG; bce:BC2437; -.
DR   PATRIC; fig|226900.8.peg.2467; -.
DR   HOGENOM; CLU_198764_0_0_9; -.
DR   OMA; QKEAPNI; -.
DR   Proteomes; UP000001417; Chromosome.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Reference proteome; Sporulation; Toxin-antitoxin system.
FT   CHAIN           1..58
FT                   /note="Stage II sporulation protein SB"
FT                   /id="PRO_0000415546"
SQ   SEQUENCE   58 AA;  6684 MW;  BAD5B7678B79FAF4 CRC64;
     MAEVNVQKSS FFKEKKEESN TDFSLVKGAL TENINRLEKL MNNSSSKYIQ VKRTKENA