SP381_ASHGO
ID SP381_ASHGO Reviewed; 264 AA.
AC Q757H5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Pre-mRNA-splicing factor SPP381;
GN Name=SPP381; OrderedLocusNames=AER038C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the spliceosome and rRNA processing machinery.
CC In association with the spliceosomal U4/U6.U5 tri-snRNP particle,
CC required for splicing of pre-mRNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex
CC of the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPP381 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52722.1; -; Genomic_DNA.
DR RefSeq; NP_984898.1; NM_210252.1.
DR AlphaFoldDB; Q757H5; -.
DR SMR; Q757H5; -.
DR STRING; 33169.AAS52722; -.
DR PRIDE; Q757H5; -.
DR EnsemblFungi; AAS52722; AAS52722; AGOS_AER038C.
DR GeneID; 4621100; -.
DR KEGG; ago:AGOS_AER038C; -.
DR eggNOG; ENOG502S80M; Eukaryota.
DR HOGENOM; CLU_1057595_0_0_1; -.
DR InParanoid; Q757H5; -.
DR OMA; WFERQNE; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..264
FT /note="Pre-mRNA-splicing factor SPP381"
FT /id="PRO_0000324505"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 29198 MW; 19691A43F3DCDB9B CRC64;
MAIRHFRRQR EQVTSGSSSD TETSDVSEQD TGAGEGPTEA ETRAEGAEQG AWERAPSVAG
SEAGESDEDD SESSSSDDEE VVLHRPVFLK KRDPGAGPAA RTGAVSGAQE RTLDQVQHHN
AVQDKERALK QIATSYSTDK ELLHRIAQLE TDGDTDSDSE RREHELWAQR RHQRMLRLRE
EERRRQSELE ENEAARLTNS ALPMDDAGIQ TAGGAERGTR PASSSDARKR RGPEAKFKPS
KVQKPQLKRT ASPSRADENE FSIL
