ID   SP381_KLULA             Reviewed;         262 AA.
AC   Q6CJ60;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Pre-mRNA-splicing factor SPP381;
GN   Name=SPP381; OrderedLocusNames=KLLA0F21142g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the spliceosome and rRNA processing machinery.
CC       In association with the spliceosomal U4/U6.U5 tri-snRNP particle,
CC       required for splicing of pre-mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex
CC       of the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP381 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98737.1; -; Genomic_DNA.
DR   RefSeq; XP_456029.1; XM_456029.1.
DR   AlphaFoldDB; Q6CJ60; -.
DR   STRING; 28985.XP_456029.1; -.
DR   EnsemblFungi; CAG98737; CAG98737; KLLA0_F21142g.
DR   GeneID; 2895435; -.
DR   KEGG; kla:KLLA0_F21142g; -.
DR   eggNOG; ENOG502S80M; Eukaryota.
DR   HOGENOM; CLU_1061961_0_0_1; -.
DR   InParanoid; Q6CJ60; -.
DR   OMA; WFERQNE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR009730; MFAP1_C.
DR   Pfam; PF06991; MFAP1; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..262
FT                   /note="Pre-mRNA-splicing factor SPP381"
FT                   /id="PRO_0000324506"
FT   REGION          1..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   262 AA;  29640 MW;  E1638A2824CA3ECE CRC64;
     MAIRHFKKQV QESSDSENSS SDEKSTTARD DNYSSNPMNE SELHLSTKAN SDSDSGKDGP
     DSSSSSSSSS SSSSDDEVTL HKPVFLKRKR KDEQNQPEET GENGSLVRAA YLAKALRQKQ
     YTENIVASET SDQSILSQII AIDDTDNTNP EQEQLQWEQR QQARLKRERQ KKLDKQLLIE
     EQEMQRASQL SKVDDPWLKE LDLNDDSNLN SFDLKASSRN RHPVNSKKDI SIPARLQKGQ
     LQLASSHTNN DTEDTEYGYI EE