ID   SP381_VANPO             Reviewed;         261 AA.
AC   A7TEH5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Pre-mRNA-splicing factor SPP381;
GN   Name=SPP381; ORFNames=Kpol_1036p24;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the spliceosome and rRNA processing machinery.
CC       In association with the spliceosomal U4/U6.U5 tri-snRNP particle,
CC       required for splicing of pre-mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex
CC       of the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP381 family. {ECO:0000305}.
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DR   EMBL; DS480380; EDO19282.1; -; Genomic_DNA.
DR   RefSeq; XP_001647140.1; XM_001647090.1.
DR   AlphaFoldDB; A7TEH5; -.
DR   SMR; A7TEH5; -.
DR   STRING; 436907.A7TEH5; -.
DR   EnsemblFungi; EDO19282; EDO19282; Kpol_1036p24.
DR   GeneID; 5547618; -.
DR   KEGG; vpo:Kpol_1036p24; -.
DR   eggNOG; ENOG502S80M; Eukaryota.
DR   HOGENOM; CLU_1066318_0_0_1; -.
DR   InParanoid; A7TEH5; -.
DR   OMA; WFERQNE; -.
DR   OrthoDB; 1643774at2759; -.
DR   PhylomeDB; A7TEH5; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..261
FT                   /note="Pre-mRNA-splicing factor SPP381"
FT                   /id="PRO_0000324507"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..229
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  30001 MW;  54B1D5B92EA6B7BE CRC64;
     MAIRHVKRRY SESSESSSSD ESVVDSTEIS VDINDDDAVK PDNEESQLEG ERDMATNDGM
     ENNGCSDLSS DSEDSSSEES DEEPVFQRPI FIKRNQLAEV TDSNNQGNVL RRIEHENKVV
     EQNEEAKKQI ATNYTTDKEI LMKAMSLNDN DLIDPEGERL RWLERQKIRK EKYRKKLIDK
     QLELEEYEAN KLLNRDIDKL EENTTTTTGE KDIPIKKSNR INNNKGDNEF KPKRVVNVTF
     KSLDDNETSA VANEDSEYSI L