ID   SP381_YEAS7             Reviewed;         216 AA.
AC   A6ZL94;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Pre-mRNA-splicing factor SPP381;
DE   AltName: Full=Suppressor of PRP38-1 mutation;
GN   Name=SPP381; ORFNames=SCY_0364;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Component of the spliceosome and rRNA processing machinery.
CC       In association with the spliceosomal U4/U6.U5 tri-snRNP particle,
CC       required for splicing of pre-mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex
CC       of the spliceosome. Interacts with PRP38 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP381 family. {ECO:0000305}.
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DR   EMBL; AAFW02000011; EDN64763.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZL94; -.
DR   EnsemblFungi; EDN64763; EDN64763; SCY_0364.
DR   HOGENOM; CLU_1107827_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Ribonucleoprotein; RNA-binding;
KW   Spliceosome.
FT   CHAIN           1..216
FT                   /note="Pre-mRNA-splicing factor SPP381"
FT                   /id="PRO_0000324508"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..81
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..216
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  25178 MW;  1728040DD47B82B3 CRC64;
     MSFRHFKRRL DTSSADESSS ADEEHPDQNV SLTEKSTSLS HSDLGGEILN DTGKNRTPND
     GQESNESDES PESEESSDNS DSSDSDDMRP LPRPLFMKKK ANNLQKATKI DQPWNTQDDA
     RVLQTKKENM IKNIDKANQV AKNYETMKLR LNTNYSTNEE LIKQCMLLDD NDEVDSEKER
     QKWFERQNER KQKHRRIQLA KQRESEEYEA KRFEAM