ID   SP39_BRUAB              Reviewed;         421 AA.
AC   O06875; Q578H9;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 3.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Probable sugar-binding periplasmic protein;
DE   AltName: Full=Immunogenic 39 kDa protein;
DE   AltName: Full=P39;
DE   Flags: Precursor;
GN   OrderedLocusNames=BruAb2_0537;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=544 / Biovar 1;
RX   PubMed=9009303; DOI=10.1128/iai.65.2.495-502.1997;
RA   Denoel P.A., Vo T.K., Tibor A., Weynants V.E., Trunde J.M., Dubray G.,
RA   Limet J.N., Letesson J.-J.;
RT   "Characterization, occurrence, and molecular cloning of a 39-kilodalton
RT   Brucella abortus cytoplasmic protein immunodominant in cattle.";
RL   Infect. Immun. 65:495-502(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA   Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison to
RT   the highly similar genomes of Brucella melitensis and Brucella suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
RN   [3]
RP   3D-STRUCTURE MODELING.
RX   PubMed=10235622; DOI=10.1093/protein/12.3.217;
RA   de Fays K., Tibor A., Lambert C., Vinals C., Denoel P., De Bolle X.,
RA   Wouters J., Letesson J.-J., Depiereux E.;
RT   "Structure and function prediction of the Brucella abortus P39 protein by
RT   comparative modeling with marginal sequence similarities.";
RL   Protein Eng. 12:217-223(1999).
CC   -!- FUNCTION: Part of a binding-protein-dependent transport system for a
CC       sugar. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- MISCELLANEOUS: Immunogenic in cattle.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB50572.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF360361; AAB50572.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE017224; AAX75955.1; -; Genomic_DNA.
DR   RefSeq; WP_002967274.1; NC_006933.1.
DR   AlphaFoldDB; O06875; -.
DR   SMR; O06875; -.
DR   EnsemblBacteria; AAX75955; AAX75955; BruAb2_0537.
DR   GeneID; 3827287; -.
DR   KEGG; bmb:BruAb2_0537; -.
DR   HOGENOM; CLU_031285_15_0_5; -.
DR   OMA; NWLWINP; -.
DR   Proteomes; UP000000540; Chromosome II.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006059; SBP.
DR   Pfam; PF01547; SBP_bac_1; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Periplasm; Signal; Sugar transport; Transport.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..421
FT                   /note="Probable sugar-binding periplasmic protein"
FT                   /id="PRO_0000031708"
FT   CONFLICT        14
FT                   /note="A -> S (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        140
FT                   /note="A -> R (in Ref. 1; AAB50572)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        415
FT                   /note="A -> V (in Ref. 1; AAB50572)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  45147 MW;  609F73B4D4967476 CRC64;
     MHKLLKLAAM GTAACALLAG MAPVANAQEK QNVEVLHWWT SGGEASALEV LKKDLESKGI
     SWTDMPVAGG GGTEAMTVLR ARVTAGNAPT AVQMLGFDIR DWAEQGALGN LDTVASKEGW
     EKVIPAPLQE FAKYDGHWIA APVNIHSTNW MWINKAALDK AGGKEPTNWD ELIALLDNFK
     AQGITPIAHG GQPWQDATIF DAVVLSFGPD FYKKAFIDLD PEALGSDTMK QAFDRMSKLR
     TYVDDNFSGR DWNLASAMVI EGKAGVQFMG DWAKGEFLKA GKKPGEDFVC MRYPGTQGAV
     TFNSDMFAMF KVSEDKVPAQ LEMASAIESP AFQSAFNVVK GSAPARTDVP DTAFDACGKK
     AIADVKEANS KGTLLGSMAH GYANPAAVKN AIYDVVTRQF NGQLSSEDAV KELVAAVEAA
     K