ID   SP4_BOMTE               Reviewed;          20 AA.
AC   P0CH88;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=Venom protease;
DE            EC=3.4.21.-;
DE   AltName: Allergen=Bom t 4;
DE   Flags: Fragment;
OS   Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Bombus; Bombus.
OX   NCBI_TaxID=30195;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND ALLERGEN.
RC   TISSUE=Venom;
RX   PubMed=11692115; DOI=10.1067/mai.2001.119029;
RA   Hoffman D.R., El-Choufani S.E., Smith M.M., de Groot H.;
RT   "Occupational allergy to bumblebees: allergens of Bombus terrestris.";
RL   J. Allergy Clin. Immunol. 108:855-860(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11692115}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:11692115}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:11692115}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0CH88; -.
DR   Allergome; 156; Bom t 4.
DR   Allergome; 3160; Bom t 4.0101.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.10; -; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   SUPFAM; SSF50494; SSF50494; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Hydrolase; Protease; Secreted; Serine protease.
FT   CHAIN           1..>20
FT                   /note="Venom protease"
FT                   /id="PRO_0000401925"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2085 MW;  B3ECC6677611C32F CRC64;
     VVGGKPAKLG AWPWMVALGF