SP5_HUMAN
ID SP5_HUMAN Reviewed; 398 AA.
AC Q6BEB4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Transcription factor Sp5;
GN Name=SP5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Takahashi M., Furukawa Y., Nakamura Y.;
RT "Isolation of human Sp5 as a direct target of the b-catenin/T-cell factor 4
RT complex and its frequent elevated expression in colon cancers.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP 9AATAD MOTIF.
RX PubMed=31375868; DOI=10.1007/s00018-019-03251-w;
RA Piskacek M., Havelka M., Jendruchova K., Knight A., Keegan L.P.;
RT "The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with
RT valines and intron reservoirs.";
RL Cell. Mol. Life Sci. 77:1793-1810(2020).
CC -!- FUNCTION: Binds to GC boxes promoters elements. Probable
CC transcriptional activator that has a role in the coordination of
CC changes in transcription required to generate pattern in the developing
CC embryo (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000269|PubMed:31375868}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AB096175; BAD34944.1; -; mRNA.
DR CCDS; CCDS33322.1; -.
DR RefSeq; NP_001003845.1; NM_001003845.2.
DR AlphaFoldDB; Q6BEB4; -.
DR SMR; Q6BEB4; -.
DR BioGRID; 132951; 2.
DR IntAct; Q6BEB4; 1.
DR STRING; 9606.ENSP00000364430; -.
DR iPTMnet; Q6BEB4; -.
DR PhosphoSitePlus; Q6BEB4; -.
DR BioMuta; SP5; -.
DR DMDM; 74762296; -.
DR jPOST; Q6BEB4; -.
DR MassIVE; Q6BEB4; -.
DR MaxQB; Q6BEB4; -.
DR PaxDb; Q6BEB4; -.
DR PeptideAtlas; Q6BEB4; -.
DR PRIDE; Q6BEB4; -.
DR ProteomicsDB; 66220; -.
DR Antibodypedia; 53490; 52 antibodies from 21 providers.
DR DNASU; 389058; -.
DR Ensembl; ENST00000375281.4; ENSP00000364430.3; ENSG00000204335.4.
DR GeneID; 389058; -.
DR KEGG; hsa:389058; -.
DR MANE-Select; ENST00000375281.4; ENSP00000364430.3; NM_001003845.3; NP_001003845.1.
DR UCSC; uc002uge.4; human.
DR CTD; 389058; -.
DR DisGeNET; 389058; -.
DR GeneCards; SP5; -.
DR HGNC; HGNC:14529; SP5.
DR HPA; ENSG00000204335; Tissue enhanced (cervix).
DR MIM; 609391; gene.
DR neXtProt; NX_Q6BEB4; -.
DR OpenTargets; ENSG00000204335; -.
DR PharmGKB; PA134875843; -.
DR VEuPathDB; HostDB:ENSG00000204335; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160673; -.
DR HOGENOM; CLU_019484_5_0_1; -.
DR InParanoid; Q6BEB4; -.
DR OMA; PGGCGHR; -.
DR OrthoDB; 1085860at2759; -.
DR PhylomeDB; Q6BEB4; -.
DR TreeFam; TF350150; -.
DR PathwayCommons; Q6BEB4; -.
DR SignaLink; Q6BEB4; -.
DR BioGRID-ORCS; 389058; 14 hits in 1096 CRISPR screens.
DR GenomeRNAi; 389058; -.
DR Pharos; Q6BEB4; Tdark.
DR PRO; PR:Q6BEB4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6BEB4; protein.
DR Bgee; ENSG00000204335; Expressed in endocervix and 90 other tissues.
DR Genevisible; Q6BEB4; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060349; P:bone morphogenesis; IEA:Ensembl.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..398
FT /note="Transcription factor Sp5"
FT /id="PRO_0000047146"
FT ZN_FING 296..320
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..350
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 356..378
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 160..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 187..195
FT /note="9aaTAD"
FT /evidence="ECO:0000269|PubMed:31375868"
FT COMPBIAS 160..179
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 75
FT /note="A -> T (in dbSNP:rs3749036)"
FT /id="VAR_052713"
SQ SEQUENCE 398 AA; 41964 MW; BC2C27EE3ED499FA CRC64;
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA PPDFLQVPYD
PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH LQPSFGAAHE LPLTPPADPS
YPYEFSPVKM LPSSMAALPA SCAPAYVPYA AQAALPPGYS NLLPPPPPPP PPPTCRQLSP
NPAPDDLPWW SIPQAGAGPG ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL
VLGPSDFAQY QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH TGEKRFACPE
CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL
