SP60_DICDI
ID SP60_DICDI Reviewed; 424 AA.
AC P15270; Q54ZS6;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Spore coat protein SP60;
DE Flags: Precursor;
GN Name=cotC; Synonyms=SP60; ORFNames=DDB_G0277141;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2601718; DOI=10.1128/mcb.9.11.5215-5218.1989;
RA Fosnaugh K.L., Loomis W.F.;
RT "Spore coat genes SP60 and SP70 of Dictyostelium discoideum.";
RL Mol. Cell. Biol. 9:5215-5218(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-185.
RX PubMed=2163344; DOI=10.1101/gad.4.4.596;
RA Haberstroh L., Firtel R.A.;
RT "A spatial gradient of expression of a cAMP-regulated prespore cell-type-
RT specific gene in Dictyostelium.";
RL Genes Dev. 4:596-612(1990).
RN [5]
RP SEQUENCE REVISION.
RX PubMed=2170814; DOI=10.1111/j.1365-2958.1990.tb00668.x;
RA Widdowson D.C.C., Proffitt J.A., Jagger P.S., Richards A.J., Hames B.D.;
RT "Developmental expression and characterization of the gene encoding spore
RT coat protein SP60 in Dictyostelium discoideum.";
RL Mol. Microbiol. 4:951-960(1990).
RN [6]
RP PROTEIN SEQUENCE OF 24-45.
RX PubMed=3954779; DOI=10.1016/0006-291x(86)90982-4;
RA Dowds B.C., Loomis W.F.;
RT "Hexapeptide repeat structure in Dictyostelium spore coat protein.";
RL Biochem. Biophys. Res. Commun. 135:336-339(1986).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X51892; CAA36174.1; -; Genomic_DNA.
DR EMBL; M26239; AAA33251.1; -; Genomic_DNA.
DR EMBL; AAFI02000019; EAL68756.1; -; Genomic_DNA.
DR EMBL; X52105; CAA36325.1; -; Genomic_DNA.
DR PIR; S11676; S11676.
DR RefSeq; XP_642790.1; XM_637698.1.
DR AlphaFoldDB; P15270; -.
DR STRING; 44689.DDB0185189; -.
DR PaxDb; P15270; -.
DR EnsemblProtists; EAL68756; EAL68756; DDB_G0277141.
DR GeneID; 8620983; -.
DR KEGG; ddi:DDB_G0277141; -.
DR dictyBase; DDB_G0277141; cotC.
DR HOGENOM; CLU_648001_0_0_1; -.
DR PhylomeDB; P15270; -.
DR PRO; PR:P15270; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0090665; C:glycoprotein complex; IDA:dictyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:dictyBase.
DR GO; GO:0031160; C:spore wall; IDA:dictyBase.
DR GO; GO:0003677; F:DNA binding; ISS:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; TAS:dictyBase.
DR GO; GO:0042244; P:spore wall assembly; IMP:dictyBase.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
DR InterPro; IPR003645; Fol_N.
DR SMART; SM00274; FOLN; 6.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Repeat; Signal; Sporulation.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:3954779"
FT CHAIN 24..424
FT /note="Spore coat protein SP60"
FT /id="PRO_0000032670"
FT DOMAIN 52..74
FT /note="Follistatin-like 1"
FT DOMAIN 85..109
FT /note="Follistatin-like 2"
FT DOMAIN 117..139
FT /note="Follistatin-like 3"
FT DOMAIN 184..206
FT /note="Follistatin-like 4"
FT DOMAIN 215..234
FT /note="Follistatin-like 5"
FT DOMAIN 299..322
FT /note="Follistatin-like 6"
FT REGION 330..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..424
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="N -> D (in Ref. 6; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 424 AA; 49306 MW; 9D8F57C869561EC4 CRC64;
MKILSLLVVG ALCMGGKVYG EVNGDWNNNG DWNNNGDWNN NGDWNNNGPI LDCSTLQCPP
RYHCEVNNGN RQCVEDQITL PPFDKCDNVH CPKGFNCKYD WEKDLALCVP WRPYPPVCRT
RCPEGHECKV DEWGKECCVK IKCDDICDLR CPKGHECKIK HDGSKCCVRS WRPRPHKPHP
RPPICRLRCP PGHECKHDEH GKECCVKKRH HDRCDLKCKR GYECKIKHDG SKCCVKRTPK
RPCCKPNSCA RDEKCVATKD RIICVKPTCD NTRCPPNYHC ICGDKIDGVK CVPDCKKARC
DDVECPDFHR CVERRGGILS CEFDPPRQPR SLDWAENEND DRDYDDRDYD DDEYDGDYDG
RDGDYDGDYD GDYDDDNYYG DDDYDNDWDN DNDWGNDWDN DWDNEDGDNW NDDDFQDAND
EWDY
