SP6_HUMAN
ID SP6_HUMAN Reviewed; 376 AA.
AC Q3SY56; B3KXS4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Transcription factor Sp6;
DE AltName: Full=Krueppel-like factor 14;
GN Name=SP6; Synonyms=KLF14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP 9AATAD MOTIF.
RX PubMed=31375868; DOI=10.1007/s00018-019-03251-w;
RA Piskacek M., Havelka M., Jendruchova K., Knight A., Keegan L.P.;
RT "The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with
RT valines and intron reservoirs.";
RL Cell. Mol. Life Sci. 77:1793-1810(2020).
CC -!- FUNCTION: Promotes cell proliferation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3SY56; P27797: CALR; NbExp=3; IntAct=EBI-11175533, EBI-1049597;
CC Q3SY56; P36957: DLST; NbExp=3; IntAct=EBI-11175533, EBI-351007;
CC Q3SY56; P42858: HTT; NbExp=3; IntAct=EBI-11175533, EBI-466029;
CC Q3SY56; Q96EH3: MALSU1; NbExp=3; IntAct=EBI-11175533, EBI-2339737;
CC Q3SY56; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-11175533, EBI-1055945;
CC Q3SY56; P17612: PRKACA; NbExp=3; IntAct=EBI-11175533, EBI-476586;
CC Q3SY56; P49810: PSEN2; NbExp=3; IntAct=EBI-11175533, EBI-2010251;
CC Q3SY56; P00441: SOD1; NbExp=3; IntAct=EBI-11175533, EBI-990792;
CC Q3SY56; P37173: TGFBR2; NbExp=3; IntAct=EBI-11175533, EBI-296151;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000269|PubMed:31375868}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AK127850; BAG54586.1; -; mRNA.
DR EMBL; CH471109; EAW94789.1; -; Genomic_DNA.
DR EMBL; BC103951; AAI03952.1; -; mRNA.
DR EMBL; BC103952; AAI03953.1; -; mRNA.
DR EMBL; BC103953; AAI03954.1; -; mRNA.
DR EMBL; BC103954; AAI03955.1; -; mRNA.
DR CCDS; CCDS11520.1; -.
DR RefSeq; NP_001245177.1; NM_001258248.1.
DR RefSeq; NP_954871.1; NM_199262.2.
DR RefSeq; XP_006722178.1; XM_006722115.3.
DR AlphaFoldDB; Q3SY56; -.
DR BioGRID; 123233; 20.
DR IntAct; Q3SY56; 21.
DR STRING; 9606.ENSP00000438209; -.
DR iPTMnet; Q3SY56; -.
DR PhosphoSitePlus; Q3SY56; -.
DR BioMuta; SP6; -.
DR DMDM; 82582258; -.
DR EPD; Q3SY56; -.
DR jPOST; Q3SY56; -.
DR MassIVE; Q3SY56; -.
DR MaxQB; Q3SY56; -.
DR PaxDb; Q3SY56; -.
DR PeptideAtlas; Q3SY56; -.
DR PRIDE; Q3SY56; -.
DR ProteomicsDB; 61841; -.
DR Antibodypedia; 30206; 174 antibodies from 25 providers.
DR DNASU; 80320; -.
DR Ensembl; ENST00000342234.3; ENSP00000340799.2; ENSG00000189120.5.
DR Ensembl; ENST00000536300.2; ENSP00000438209.1; ENSG00000189120.5.
DR GeneID; 80320; -.
DR KEGG; hsa:80320; -.
DR MANE-Select; ENST00000536300.2; ENSP00000438209.1; NM_001258248.2; NP_001245177.1.
DR UCSC; uc002img.3; human.
DR CTD; 80320; -.
DR DisGeNET; 80320; -.
DR GeneCards; SP6; -.
DR HGNC; HGNC:14530; SP6.
DR HPA; ENSG00000189120; Tissue enhanced (placenta, skin).
DR MIM; 608613; gene.
DR neXtProt; NX_Q3SY56; -.
DR OpenTargets; ENSG00000189120; -.
DR PharmGKB; PA37892; -.
DR VEuPathDB; HostDB:ENSG00000189120; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161498; -.
DR HOGENOM; CLU_019484_0_0_1; -.
DR InParanoid; Q3SY56; -.
DR OMA; LPHAQGT; -.
DR OrthoDB; 1085860at2759; -.
DR PhylomeDB; Q3SY56; -.
DR TreeFam; TF315506; -.
DR PathwayCommons; Q3SY56; -.
DR SignaLink; Q3SY56; -.
DR BioGRID-ORCS; 80320; 15 hits in 1098 CRISPR screens.
DR ChiTaRS; SP6; human.
DR GenomeRNAi; 80320; -.
DR Pharos; Q3SY56; Tbio.
DR PRO; PR:Q3SY56; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q3SY56; protein.
DR Bgee; ENSG00000189120; Expressed in lower esophagus mucosa and 109 other tissues.
DR Genevisible; Q3SY56; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..376
FT /note="Transcription factor Sp6"
FT /id="PRO_0000047148"
FT ZN_FING 254..278
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..308
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 118..126
FT /note="9aaTAD"
FT /evidence="ECO:0000269|PubMed:31375868"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 156
FT /note="V -> I (in dbSNP:rs34309518)"
FT /id="VAR_052714"
SQ SEQUENCE 376 AA; 39840 MW; 1F4355CFB75206E8 CRC64;
MLTAVCGSLG SQHTEAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG ELQSLPLGPE
VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM SHHYESWFRP THPGAEDGSW
WDLHPGTSWM DLPHTQGALT SPGHPGALQA GLGGYVGDHQ LCAPPPHPHA HHLLPAAGGQ
HLLGPPDGAK ALEVAAPESQ GLDSSLDGAA RPKGSRRSVP RSSGQTVCRC PNCLEAERLG
APCGPDGGKK KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAGAASGE GKAGGAVEPP
GGKGKREAEG SVAPSN
