SP6_MOUSE
ID SP6_MOUSE Reviewed; 376 AA.
AC Q9ESX2; Q6VM22;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Transcription factor Sp6;
DE AltName: Full=Epiprofin;
DE AltName: Full=Krueppel-like factor 14;
GN Name=Sp6; Synonyms=Epfn, Klf14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=ICR;
RX PubMed=14551215; DOI=10.1074/jbc.m307502200;
RA Nakamura T., Unda F., De-Vega S., Vilaxa A., Fukumoto S., Yamada K.M.,
RA Yamada Y.;
RT "The Kruppel-like factor epiprofin is expressed by epithelium of developing
RT teeth, hair follicles, and limb buds and promotes cell proliferation.";
RL J. Biol. Chem. 279:626-634(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 225-376.
RX PubMed=11087666; DOI=10.1006/geno.2000.6362;
RA Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L.,
RA Van Vooren P., Riviere M., Szpirer J., Szpirer C.;
RT "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF
RT transcription factor family.";
RL Genomics 70:93-101(2000).
CC -!- FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:14551215}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14551215}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Preferentially expressed by
CC proliferating epithelial cells of teeth, hair follicles and limbs.
CC {ECO:0000269|PubMed:14551215}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:Q3SY56}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AY338955; AAR01258.1; -; mRNA.
DR EMBL; AJ275988; CAC06698.1; -; mRNA.
DR CCDS; CCDS25309.1; -.
DR RefSeq; NP_112460.1; NM_031183.2.
DR RefSeq; XP_006534594.1; XM_006534531.3.
DR AlphaFoldDB; Q9ESX2; -.
DR STRING; 10090.ENSMUSP00000039307; -.
DR iPTMnet; Q9ESX2; -.
DR PhosphoSitePlus; Q9ESX2; -.
DR MaxQB; Q9ESX2; -.
DR PaxDb; Q9ESX2; -.
DR PRIDE; Q9ESX2; -.
DR ProteomicsDB; 257290; -.
DR Antibodypedia; 30206; 174 antibodies from 25 providers.
DR DNASU; 83395; -.
DR Ensembl; ENSMUST00000047997; ENSMUSP00000039307; ENSMUSG00000038560.
DR Ensembl; ENSMUST00000107622; ENSMUSP00000103248; ENSMUSG00000038560.
DR GeneID; 83395; -.
DR KEGG; mmu:83395; -.
DR UCSC; uc007ldh.2; mouse.
DR CTD; 80320; -.
DR MGI; MGI:1932575; Sp6.
DR VEuPathDB; HostDB:ENSMUSG00000038560; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161498; -.
DR HOGENOM; CLU_019484_0_0_1; -.
DR InParanoid; Q9ESX2; -.
DR OMA; LPHAQGT; -.
DR OrthoDB; 1085860at2759; -.
DR PhylomeDB; Q9ESX2; -.
DR TreeFam; TF315506; -.
DR BioGRID-ORCS; 83395; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Sp6; mouse.
DR PRO; PR:Q9ESX2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9ESX2; protein.
DR Bgee; ENSMUSG00000038560; Expressed in calcareous tooth and 111 other tissues.
DR ExpressionAtlas; Q9ESX2; baseline and differential.
DR Genevisible; Q9ESX2; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042481; P:regulation of odontogenesis; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:MGI.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..376
FT /note="Transcription factor Sp6"
FT /id="PRO_0000047149"
FT ZN_FING 254..278
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..308
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 118..126
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:Q3SY56"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 40016 MW; DA41AFF6FB6593A1 CRC64;
MLTAVCGSLG SQHTDAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG ELQSLPLGPE
VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM SHHYESWFRP THPGTEDGSW
WDLHPGTSWM DLPHTQGALT SPGHPGALQP ALGGYVGDHQ LCAPPPHPHP HHLLPAAGGQ
HLLGPPDGAK ALEAAAQESQ GLDSSLDAAS RPKGSRRSVP RSSGQTVCRC PNCLEAERLG
APCGPDGGKK KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAAAAQGE GKAGGVVEPP
GGKGKREAEG SSASSN
