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SP8_MOUSE
ID   SP8_MOUSE               Reviewed;         486 AA.
AC   Q8BMJ8; Q8BWA3;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Transcription factor Sp8;
GN   Name=Sp8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=15358670; DOI=10.1242/dev.01331;
RA   Kawakami Y., Rodriguez Esteban C., Matsui T., Rodriguez-Leon J., Kato S.,
RA   Izpisua Belmonte J.C.;
RT   "Sp8 and Sp9, two closely related buttonhead-like transcription factors,
RT   regulate Fgf8 expression and limb outgrowth in vertebrate embryos.";
RL   Development 131:4763-4774(2004).
CC   -!- FUNCTION: Transcription factor which plays a key role in limb
CC       development. Positively regulates FGF8 expression in the apical
CC       ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
CC       {ECO:0000269|PubMed:15358670}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expression is detected in the forebrain,
CC       midbrain/hindbrain boundary and neural tube. At the stage of limb bud
CC       outgrowth, expressed in a scattered manner in the ventral ectoderm, and
CC       is later confined to the apical ectodermal ridge (AER).
CC       {ECO:0000269|PubMed:15358670}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:Q8IXZ3}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; AK030745; BAC27113.1; -; mRNA.
DR   EMBL; AK053093; BAC35264.1; -; mRNA.
DR   CCDS; CCDS26213.1; -.
DR   RefSeq; NP_796056.2; NM_177082.4.
DR   RefSeq; XP_006516046.1; XM_006515983.3.
DR   RefSeq; XP_006516047.1; XM_006515984.3.
DR   RefSeq; XP_006516048.1; XM_006515985.3.
DR   RefSeq; XP_006516049.1; XM_006515986.3.
DR   RefSeq; XP_006516050.1; XM_006515987.3.
DR   RefSeq; XP_006516051.1; XM_006515988.3.
DR   RefSeq; XP_011242426.1; XM_011244124.2.
DR   AlphaFoldDB; Q8BMJ8; -.
DR   SMR; Q8BMJ8; -.
DR   STRING; 10090.ENSMUSP00000065746; -.
DR   iPTMnet; Q8BMJ8; -.
DR   PhosphoSitePlus; Q8BMJ8; -.
DR   MaxQB; Q8BMJ8; -.
DR   PaxDb; Q8BMJ8; -.
DR   PRIDE; Q8BMJ8; -.
DR   ProteomicsDB; 257332; -.
DR   Antibodypedia; 53277; 68 antibodies from 15 providers.
DR   DNASU; 320145; -.
DR   Ensembl; ENSMUST00000063918; ENSMUSP00000065746; ENSMUSG00000048562.
DR   GeneID; 320145; -.
DR   KEGG; mmu:320145; -.
DR   UCSC; uc007pig.2; mouse.
DR   CTD; 221833; -.
DR   MGI; MGI:2443471; Sp8.
DR   VEuPathDB; HostDB:ENSMUSG00000048562; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162033; -.
DR   HOGENOM; CLU_019484_4_1_1; -.
DR   InParanoid; Q8BMJ8; -.
DR   OMA; MYSRHPY; -.
DR   OrthoDB; 664813at2759; -.
DR   PhylomeDB; Q8BMJ8; -.
DR   TreeFam; TF350150; -.
DR   BioGRID-ORCS; 320145; 3 hits in 74 CRISPR screens.
DR   PRO; PR:Q8BMJ8; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q8BMJ8; protein.
DR   Bgee; ENSMUSG00000048562; Expressed in rostral migratory stream and 64 other tissues.
DR   ExpressionAtlas; Q8BMJ8; baseline and differential.
DR   Genevisible; Q8BMJ8; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IMP:UniProtKB.
DR   GO; GO:0009954; P:proximal/distal pattern formation; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..486
FT                   /note="Transcription factor Sp8"
FT                   /id="PRO_0000047153"
FT   ZN_FING         356..380
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         386..410
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         416..438
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           208..216
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXZ3"
FT   COMPBIAS        8..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  48417 MW;  336C36B548646883 CRC64;
     MLAATCNKIG SPSPSPSSLS DSSSSFGKGF HPWKRSSSSS SGSCNVVGSS LSSFGVSGAS
     RNGGSSSAAA AAAAAAAAAA ALVSDSFSCG GSPGSSAFSL TSSSAAAAAA AAAAAASSSP
     FANDYSVFQA PGVSGGSGGG GGGGGGGSGA HSQDSSHQPV FISKVHTSVD GLQGIYPRVG
     MAHPYESWFK PSHPGLGAAA DVGSAGASSW WDVGAGWIDV QNPNGAAALP GSLHPAAGGL
     QTSLHSPLGG YNSDYSGLSH SAFSSGASSH LLSPAGQHLM DGFKPVLPGS YPDSAPSPLA
     GAGSSMLSAG PAAQLGGSPR SSARRYSGRA TCDCPNCQEA ERLGPAGASL RRKGLHSCHI
     PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKRFTRS DELQRHLRTH TGEKRFACPV
     CNKRFMRSDH LSKHVKTHSG GGGSAGSGGG KKGSDTDSEH SAAGSPPCHS PELLQPPEPG
     HRNGLE
 
 
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