ID   SP9_XENTR               Reviewed;         422 AA.
AC   Q0VA40;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Transcription factor Sp9;
GN   Name=sp9;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which plays a key role in limb
CC       development. Positively regulates FGF8 expression in the apical
CC       ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors. In SP9, the motif is
CC       inactive. {ECO:0000250|UniProtKB:P0CG40}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC121268; AAI21269.1; -; mRNA.
DR   RefSeq; NP_001072269.1; NM_001078801.1.
DR   AlphaFoldDB; Q0VA40; -.
DR   SMR; Q0VA40; -.
DR   STRING; 8364.ENSXETP00000062650; -.
DR   PaxDb; Q0VA40; -.
DR   DNASU; 779722; -.
DR   Ensembl; ENSXETT00000064701; ENSXETP00000062650; ENSXETG00000030987.
DR   GeneID; 779722; -.
DR   KEGG; xtr:779722; -.
DR   CTD; 100131390; -.
DR   Xenbase; XB-GENE-5931012; sp9.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_019484_4_1_1; -.
DR   InParanoid; Q0VA40; -.
DR   OMA; HHHATSV; -.
DR   OrthoDB; 664813at2759; -.
DR   PhylomeDB; Q0VA40; -.
DR   TreeFam; TF350150; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000030987; Expressed in brain and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR   GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR   GO; GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..422
FT                   /note="Transcription factor Sp9"
FT                   /id="PRO_0000395453"
FT   ZN_FING         295..319
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         325..349
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         355..377
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          372..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           163..171
FT                   /note="9aaTAD; inactive"
FT                   /evidence="ECO:0000250|UniProtKB:P0CG40"
SQ   SEQUENCE   422 AA;  43913 MW;  0019EB87454EA65C CRC64;
     MATSILGEEP RFGTTPLAML AATCNKIGNT SPLSSLPESS AFAKGGFHPW KRSSSSCSLG
     SSLGGFAVAT SRASGALTGG TATANSAFCL ASTSPTSSAF SSDYSGLFSS ASGVSPQESA
     GQSAFISKVH ASAEGLYPRV GMAHPYESWY KSGFHSDVSG GASAWWDVHA AGPSTWLEVQ
     NTQGALHSGA AAHGQLGAYS PDFSSLTHSA FSSTGASHLL PGGQHLLTQD AFKPVLPSYP
     DSGGPMLSGA AGTGAGGTGR SARRYSGRAT CDCPNCQEAE RLGPAGASLR RKGLHSCHIP
     GCGKVYGKTS HLKAHLRWHT GERPFVCNWL FCGKRFTRSD ELQRHLRTHT GEKRFACPVC
     NKRFMRSDHL SKHIKTHNGG GGGGKKGSDS DTDASNLETP RSESPELIME GVRPGKDSGN
     DS