ID   SPA11_HUMAN             Reviewed;         422 AA.
AC   Q86U17; B2RV07;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Serpin A11;
DE   Flags: Precursor;
GN   Name=SERPINA11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal liver;
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD62587.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX248259; CAD62587.1; ALT_INIT; mRNA.
DR   EMBL; BC146962; AAI46963.1; -; mRNA.
DR   CCDS; CCDS32149.1; -.
DR   RefSeq; NP_001073920.1; NM_001080451.1.
DR   AlphaFoldDB; Q86U17; -.
DR   SMR; Q86U17; -.
DR   BioGRID; 129165; 1.
DR   IntAct; Q86U17; 1.
DR   STRING; 9606.ENSP00000335024; -.
DR   GlyGen; Q86U17; 4 sites.
DR   BioMuta; SERPINA11; -.
DR   DMDM; 76363411; -.
DR   jPOST; Q86U17; -.
DR   MassIVE; Q86U17; -.
DR   PaxDb; Q86U17; -.
DR   PeptideAtlas; Q86U17; -.
DR   PRIDE; Q86U17; -.
DR   ProteomicsDB; 69759; -.
DR   Antibodypedia; 56616; 142 antibodies from 22 providers.
DR   DNASU; 256394; -.
DR   Ensembl; ENST00000334708.4; ENSP00000335024.3; ENSG00000186910.4.
DR   GeneID; 256394; -.
DR   KEGG; hsa:256394; -.
DR   MANE-Select; ENST00000334708.4; ENSP00000335024.3; NM_001080451.2; NP_001073920.1.
DR   UCSC; uc001ydd.2; human.
DR   CTD; 256394; -.
DR   DisGeNET; 256394; -.
DR   GeneCards; SERPINA11; -.
DR   HGNC; HGNC:19193; SERPINA11.
DR   HPA; ENSG00000186910; Tissue enriched (liver).
DR   MIM; 619619; gene.
DR   neXtProt; NX_Q86U17; -.
DR   OpenTargets; ENSG00000186910; -.
DR   PharmGKB; PA134988362; -.
DR   VEuPathDB; HostDB:ENSG00000186910; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000162010; -.
DR   HOGENOM; CLU_023330_2_1_1; -.
DR   InParanoid; Q86U17; -.
DR   OMA; CQPFPAH; -.
DR   OrthoDB; 1124079at2759; -.
DR   PhylomeDB; Q86U17; -.
DR   TreeFam; TF343201; -.
DR   PathwayCommons; Q86U17; -.
DR   SignaLink; Q86U17; -.
DR   BioGRID-ORCS; 256394; 10 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 256394; -.
DR   Pharos; Q86U17; Tdark.
DR   PRO; PR:Q86U17; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q86U17; protein.
DR   Bgee; ENSG00000186910; Expressed in right lobe of liver and 38 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..422
FT                   /note="Serpin A11"
FT                   /id="PRO_0000041973"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        350
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         230
FT                   /note="E -> A (in dbSNP:rs1885137)"
FT                   /id="VAR_061791"
FT   VARIANT         406
FT                   /note="T -> S (in dbSNP:rs17752285)"
FT                   /id="VAR_034511"
SQ   SEQUENCE   422 AA;  46989 MW;  58536B32C91DC2F8 CRC64;
     MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI TPTITNFALR
     LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL EGLGFNLTET PEADIHQGFR
     SLLHTLALPS PKLELKVGNS LFLDKRLKPR QHYLDSIKEL YGAFAFSANF TDSVTTGRQI
     NDYLRRQTYG QVVDCLPEFS QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL
     QVPMMHQKEM HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG
     QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN KTISKVSHKA
     MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPV
     AG