SPA11_MOUSE
ID SPA11_MOUSE Reviewed; 424 AA.
AC Q8CIE0;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Serpin A11;
DE Flags: Precursor;
GN Name=Serpina11; Synonyms=Gm895;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR EMBL; BC024087; AAH24087.1; -; mRNA.
DR EMBL; BC096585; AAH96585.1; -; mRNA.
DR RefSeq; NP_955018.2; NM_199314.2.
DR AlphaFoldDB; Q8CIE0; -.
DR SMR; Q8CIE0; -.
DR STRING; 10090.ENSMUSP00000074258; -.
DR GlyGen; Q8CIE0; 4 sites.
DR CPTAC; non-CPTAC-4011; -.
DR MaxQB; Q8CIE0; -.
DR PaxDb; Q8CIE0; -.
DR PRIDE; Q8CIE0; -.
DR ProteomicsDB; 261488; -.
DR DNASU; 380780; -.
DR GeneID; 380780; -.
DR KEGG; mmu:380780; -.
DR CTD; 256394; -.
DR MGI; MGI:2685741; Serpina11.
DR eggNOG; KOG2392; Eukaryota.
DR InParanoid; Q8CIE0; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; Q8CIE0; -.
DR BioGRID-ORCS; 380780; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8CIE0; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CIE0; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..424
FT /note="Serpin A11"
FT /id="PRO_0000041974"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 352
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 424 AA; 47188 MW; D176AAF8D5A06D34 CRC64;
MGPVWLWLWL LVAEVLLPVH CQPFSAHGDK SLGASQPASH QSLEPAPAYH KVTPTITNFA
LRLYKQLAEE VAGNILFSPV SLSSSLALLS LGAHADTQTQ ILESLGFNLT ETPAADVHRG
FQSLLHTLDL PSPKLELKLG HSLFLDRQLK PQQRFLDSAK ELYGALAFSA NFTEAAATGQ
QINDLVRKQT YGQVVGCLPE FSHDTLMVLL NYIFFKAKWK HPFDRYQTRK QESFSLDQRT
PLRIPMMRQK EMHRFLYDQE ASCTVLQIEY SGTALLLLVL PDPGKMQQVE AALQPETLRR
WGQRFLPSLL DLHLPRFSIS ATYNLEEILP LIGLGNLFDM EADLSGIMGQ LNKTVSRVSH
KAIVDMNEKG TEAAAASGLL SQPPALNMTS APQAHYNRPF LLLLWEVTTQ SLLFLGKVVN
PAAG
