ID   SPA11_RAT               Reviewed;         422 AA.
AC   Q7TPA5; Q2M2R9;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Serpin A11;
DE   AltName: Full=Liver regeneration-related protein LRRG023;
DE   Flags: Precursor;
GN   Name=Serpina11; ORFNames=Ab1-046;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Liver;
RA   Xu C.S., Li W.Q., Li Y.C., Yang K.J., Yan H.M., Chang C.F., Zhao L.F.,
RA   Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7TPA5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7TPA5-2; Sequence=VSP_021274;
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AY325135; AAP92536.1; -; mRNA.
DR   EMBL; BC111708; AAI11709.1; -; mRNA.
DR   RefSeq; NP_001008776.1; NM_001008776.2. [Q7TPA5-2]
DR   RefSeq; NP_001159824.1; NM_001166352.1. [Q7TPA5-1]
DR   RefSeq; XP_006240543.1; XM_006240481.2. [Q7TPA5-2]
DR   AlphaFoldDB; Q7TPA5; -.
DR   SMR; Q7TPA5; -.
DR   STRING; 10116.ENSRNOP00000041705; -.
DR   GlyGen; Q7TPA5; 4 sites.
DR   iPTMnet; Q7TPA5; -.
DR   PRIDE; Q7TPA5; -.
DR   Ensembl; ENSRNOT00000015516; ENSRNOP00000015516; ENSRNOG00000011141. [Q7TPA5-1]
DR   Ensembl; ENSRNOT00000047324; ENSRNOP00000041705; ENSRNOG00000011141. [Q7TPA5-2]
DR   GeneID; 362774; -.
DR   KEGG; rno:362774; -.
DR   UCSC; RGD:1359239; rat. [Q7TPA5-1]
DR   CTD; 256394; -.
DR   RGD; 1359239; Serpina11.
DR   eggNOG; KOG2392; Eukaryota.
DR   GeneTree; ENSGT00940000162010; -.
DR   HOGENOM; CLU_023330_2_1_1; -.
DR   InParanoid; Q7TPA5; -.
DR   OMA; CQPFPAH; -.
DR   OrthoDB; 1124079at2759; -.
DR   PhylomeDB; Q7TPA5; -.
DR   TreeFam; TF343201; -.
DR   PRO; PR:Q7TPA5; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000011141; Expressed in liver and 8 other tissues.
DR   Genevisible; Q7TPA5; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Protease inhibitor; Reference proteome;
KW   Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..422
FT                   /note="Serpin A11"
FT                   /id="PRO_0000041975"
FT   REGION          25..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        350
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        385
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         305
FT                   /note="P -> PRKAQAGGAGNGGLHWDRVNEFPQNRVGKLSLKHLQMTQTW (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_021274"
SQ   SEQUENCE   422 AA;  47024 MW;  71F5EFF86B63E7B9 CRC64;
     MGPVWLWLLI AELLLPVHYQ PSSAHGDKSL GAPQPASHQS LEPAPAYHKV TPTITNFALR
     LYKQLAEEIP GNILFSPVSL SSTVALLSLG AHADTQAQIL QSLGFNLTET PAADIHRGFQ
     SLLHTLDLPS PKLELKLGHS LFLDRQLKPQ QRFLDSAKEL YGALAFSANF TEAAATGQQI
     NDLVRKQTYG QVVGCLPEFD RDTLMVLLNY IFFKAKWKHP FDRYQTRKQE SFFVDQRLQL
     RIPMMRQKEM HRFLYDQEAS CTVLQIEYSG TALLLLVLPD PGKMQQVEAA LQPETLRRWG
     QRFLPSLLDL HLPRFSVSAT YNLEEILPLV GLSSLFDVEA DLSGIMGQLN KTVSRVSHKA
     VVDMNEKGTE AAAASGLLSQ PPSLNMTSAP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPA
     AG