ID   SPA24_MACFA             Reviewed;         205 AA.
AC   Q4R7I4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Spermatogenesis-associated protein 24;
DE   AltName: Full=Testis protein T6441 homolog;
GN   Name=SPATA24; ORFNames=QtsA-15191;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds DNA with high affinity but does not bind to TATA boxes.
CC       Synergises with GMNN and TBP in activation of TATA box-containing
CC       promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less
CC       promoter. May play a role in cytoplasm movement and removal during
CC       spermiogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and
CC       the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Associated with
CC       chromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPATA24 family. {ECO:0000305}.
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DR   EMBL; AB168834; BAE00938.1; -; mRNA.
DR   RefSeq; NP_001306527.1; NM_001319598.1.
DR   AlphaFoldDB; Q4R7I4; -.
DR   SMR; Q4R7I4; -.
DR   STRING; 9541.XP_005557984.1; -.
DR   GeneID; 101867491; -.
DR   CTD; 202051; -.
DR   eggNOG; ENOG502S3HF; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR029176; SPATA24.
DR   PANTHER; PTHR35155; PTHR35155; 1.
DR   Pfam; PF15175; SPATA24; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Developmental protein; Differentiation;
KW   DNA-binding; Nucleus; Reference proteome; Spermatogenesis; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Spermatogenesis-associated protein 24"
FT                   /id="PRO_0000328980"
FT   REGION          138..185
FT                   /note="Required for interaction with CBX5 and TBPL1"
FT                   /evidence="ECO:0000250"
FT   REGION          180..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          17..166
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        187..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  23602 MW;  1F663340BDA28D09 CRC64;
     MATPLGWSKA GSGSVCLAFD QLRDVIESQE ELIHQLRNVM VLQDENFVSK EEFQAVEKKL
     VEEKAAHAKT KVLLAKEEEK LQFALGEVEV LSKQLEKEKL AFEKALSSVK SKVLQESSKK
     DQLITKCNEI ESHIIKQEDI LNGKENEIKE LQQVISQQKQ IFRNHMSDFR IQKQQESYMA
     QVLDQKHKKA SGTRQAHSHQ HPREK