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SPA24_RAT
ID   SPA24_RAT               Reviewed;         205 AA.
AC   Q4PJT6; D3ZAG4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 3.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Spermatogenesis-associated protein 24;
DE   AltName: Full=Testis protein T6441;
GN   Name=Spata24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RX   PubMed=16146721; DOI=10.2741/1787;
RA   Song X.-X., Li Y.-C., Shi Y.Q., Hu X.Q., Hu Z.Y., Han C.S., Liu Y.-X.;
RT   "Cloning and characterization of a novel spermiogenesis-related gene,
RT   T6441, in rat testis.";
RL   Front. Biosci. 11:143-150(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19515240; DOI=10.1186/1471-2091-10-16;
RA   Pitulescu M.E., Teichmann M., Luo L., Kessel M.;
RT   "TIPT2 and geminin interact with basal transcription factors to synergize
RT   in transcriptional regulation.";
RL   BMC Biochem. 10:16-16(2009).
CC   -!- FUNCTION: Binds DNA with high affinity but does not bind to TATA boxes.
CC       Synergises with GMNN and TBP in activation of TATA box-containing
CC       promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less
CC       promoter (By similarity). May play a role in cytoplasm movement and
CC       removal during spermiogenesis. {ECO:0000250,
CC       ECO:0000269|PubMed:16146721}.
CC   -!- SUBUNIT: Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and
CC       the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Nucleus,
CC       nucleoplasm. Note=Associated with chromatin. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q4PJT6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4PJT6-2; Sequence=VSP_039460;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the testis and is mainly
CC       localized in the spermatids. Also expressed in the lung, heart, spleen
CC       and epididymis. {ECO:0000269|PubMed:16146721}.
CC   -!- DEVELOPMENTAL STAGE: Expression is low before postnatal stage on day
CC       20, and increases significantly between days 20 to 28.
CC       {ECO:0000269|PubMed:16146721}.
CC   -!- SIMILARITY: Belongs to the SPATA24 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY83365.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DQ080016; AAY83365.1; ALT_INIT; mRNA.
DR   EMBL; CH473974; EDL76272.1; -; Genomic_DNA.
DR   RefSeq; NP_001020807.2; NM_001025636.2.
DR   RefSeq; XP_006254607.1; XM_006254545.3. [Q4PJT6-1]
DR   AlphaFoldDB; Q4PJT6; -.
DR   SMR; Q4PJT6; -.
DR   STRING; 10116.ENSRNOP00000043703; -.
DR   PaxDb; Q4PJT6; -.
DR   Ensembl; ENSRNOT00000040091; ENSRNOP00000043703; ENSRNOG00000019976. [Q4PJT6-1]
DR   GeneID; 291676; -.
DR   KEGG; rno:291676; -.
DR   UCSC; RGD:1311742; rat. [Q4PJT6-1]
DR   CTD; 202051; -.
DR   RGD; 1311742; Spata24.
DR   eggNOG; ENOG502S3HF; Eukaryota.
DR   GeneTree; ENSGT00390000007817; -.
DR   HOGENOM; CLU_115899_0_0_1; -.
DR   InParanoid; Q4PJT6; -.
DR   OMA; HITKQED; -.
DR   OrthoDB; 1521659at2759; -.
DR   PhylomeDB; Q4PJT6; -.
DR   TreeFam; TF338733; -.
DR   PRO; PR:Q4PJT6; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Proteomes; UP000234681; Chromosome 18.
DR   Bgee; ENSRNOG00000019976; Expressed in testis and 19 other tissues.
DR   Genevisible; Q4PJT6; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR029176; SPATA24.
DR   PANTHER; PTHR35155; PTHR35155; 1.
DR   Pfam; PF15175; SPATA24; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Developmental protein;
KW   Differentiation; DNA-binding; Nucleus; Reference proteome; Spermatogenesis;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Spermatogenesis-associated protein 24"
FT                   /id="PRO_0000328982"
FT   REGION          138..185
FT                   /note="Required for interaction with CBX5 and TBPL1"
FT                   /evidence="ECO:0000250"
FT   REGION          182..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          17..166
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         129..205
FT                   /note="EIESHIIKQEDILNGKENEIKELQQVISQQRQSFRNHMSDFRIQKQQETYMA
FT                   QVLDQKHKKTSGTRRARSRQCSREK -> GRREARAAPQVNIHGLFSNSPMMVPKAGLH
FT                   PNFCPRLRIQASPGGSHLRKCLQGPGRPRK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16146721"
FT                   /id="VSP_039460"
SQ   SEQUENCE   205 AA;  23718 MW;  44F3BC2F560A487C CRC64;
     MATPLGWSQG GSGSVCLAFD QLRDVIESQE ELIHQLRNVM VLQDENFVSK EEFQEVEKKL
     VDEKAAHAKT KALLAKEEEK LQFALGEVEV LSKQLEKEKM AFEKALSSVK SRVLQESSKK
     DQLITKCNEI ESHIIKQEDI LNGKENEIKE LQQVISQQRQ SFRNHMSDFR IQKQQETYMA
     QVLDQKHKKT SGTRRARSRQ CSREK
 
 
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