SPA2L_HUMAN
ID SPA2L_HUMAN Reviewed; 424 AA.
AC Q8IUW3; D3DX85; Q8NHV3;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Spermatogenesis-associated protein 2-like protein {ECO:0000305};
DE Short=SPATA2-like protein {ECO:0000305};
GN Name=SPATA2L {ECO:0000312|HGNC:HGNC:28393};
GN Synonyms=C16orf76 {ECO:0000312|HGNC:HGNC:28393};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IUW3; Q92870-2: APBB2; NbExp=3; IntAct=EBI-2510414, EBI-21535880;
CC Q8IUW3; P02649: APOE; NbExp=3; IntAct=EBI-2510414, EBI-1222467;
CC Q8IUW3; P05067-2: APP; NbExp=3; IntAct=EBI-2510414, EBI-17264467;
CC Q8IUW3; P54253: ATXN1; NbExp=3; IntAct=EBI-2510414, EBI-930964;
CC Q8IUW3; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-2510414, EBI-702390;
CC Q8IUW3; P54252: ATXN3; NbExp=3; IntAct=EBI-2510414, EBI-946046;
CC Q8IUW3; P09172: DBH; NbExp=3; IntAct=EBI-2510414, EBI-8589586;
CC Q8IUW3; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-2510414, EBI-21603100;
CC Q8IUW3; P14136: GFAP; NbExp=3; IntAct=EBI-2510414, EBI-744302;
CC Q8IUW3; P62993: GRB2; NbExp=4; IntAct=EBI-2510414, EBI-401755;
CC Q8IUW3; P42858: HTT; NbExp=6; IntAct=EBI-2510414, EBI-466029;
CC Q8IUW3; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-2510414, EBI-1055254;
CC Q8IUW3; O43639: NCK2; NbExp=3; IntAct=EBI-2510414, EBI-713635;
CC Q8IUW3; Q92597: NDRG1; NbExp=3; IntAct=EBI-2510414, EBI-716486;
CC Q8IUW3; P19404: NDUFV2; NbExp=3; IntAct=EBI-2510414, EBI-713665;
CC Q8IUW3; P29474: NOS3; NbExp=3; IntAct=EBI-2510414, EBI-1391623;
CC Q8IUW3; Q99497: PARK7; NbExp=3; IntAct=EBI-2510414, EBI-1164361;
CC Q8IUW3; P16284: PECAM1; NbExp=3; IntAct=EBI-2510414, EBI-716404;
CC Q8IUW3; O60260-5: PRKN; NbExp=3; IntAct=EBI-2510414, EBI-21251460;
CC Q8IUW3; Q9NUW8: TDP1; NbExp=3; IntAct=EBI-2510414, EBI-2902553;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IUW3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IUW3-2; Sequence=VSP_027332, VSP_027333;
CC -!- SIMILARITY: Belongs to the SPATA2 family. {ECO:0000305}.
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DR EMBL; CH471184; EAW66697.1; -; Genomic_DNA.
DR EMBL; CH471184; EAW66699.1; -; Genomic_DNA.
DR EMBL; CH471184; EAW66698.1; -; Genomic_DNA.
DR EMBL; BC027606; AAH27606.1; -; mRNA.
DR EMBL; BC039608; AAH39608.1; -; mRNA.
DR EMBL; BC053588; AAH53588.1; -; mRNA.
DR CCDS; CCDS10985.1; -. [Q8IUW3-1]
DR RefSeq; NP_689552.2; NM_152339.3. [Q8IUW3-1]
DR RefSeq; XP_005256336.1; XM_005256279.4. [Q8IUW3-1]
DR AlphaFoldDB; Q8IUW3; -.
DR SMR; Q8IUW3; -.
DR BioGRID; 125846; 11.
DR IntAct; Q8IUW3; 27.
DR MINT; Q8IUW3; -.
DR STRING; 9606.ENSP00000289805; -.
DR iPTMnet; Q8IUW3; -.
DR PhosphoSitePlus; Q8IUW3; -.
DR BioMuta; SPATA2L; -.
DR DMDM; 74727996; -.
DR EPD; Q8IUW3; -.
DR jPOST; Q8IUW3; -.
DR MassIVE; Q8IUW3; -.
DR PaxDb; Q8IUW3; -.
DR PeptideAtlas; Q8IUW3; -.
DR PRIDE; Q8IUW3; -.
DR ProteomicsDB; 70615; -. [Q8IUW3-1]
DR ProteomicsDB; 70616; -. [Q8IUW3-2]
DR Antibodypedia; 30904; 362 antibodies from 20 providers.
DR DNASU; 124044; -.
DR Ensembl; ENST00000289805.10; ENSP00000289805.5; ENSG00000158792.16. [Q8IUW3-1]
DR Ensembl; ENST00000335360.11; ENSP00000334006.7; ENSG00000158792.16. [Q8IUW3-2]
DR GeneID; 124044; -.
DR KEGG; hsa:124044; -.
DR MANE-Select; ENST00000289805.10; ENSP00000289805.5; NM_152339.4; NP_689552.2.
DR UCSC; uc002foj.4; human. [Q8IUW3-1]
DR CTD; 124044; -.
DR DisGeNET; 124044; -.
DR GeneCards; SPATA2L; -.
DR HGNC; HGNC:28393; SPATA2L.
DR HPA; ENSG00000158792; Low tissue specificity.
DR neXtProt; NX_Q8IUW3; -.
DR OpenTargets; ENSG00000158792; -.
DR PharmGKB; PA162404411; -.
DR VEuPathDB; HostDB:ENSG00000158792; -.
DR eggNOG; ENOG502S1TH; Eukaryota.
DR GeneTree; ENSGT00530000063956; -.
DR HOGENOM; CLU_047839_0_0_1; -.
DR InParanoid; Q8IUW3; -.
DR OMA; QAHSCLA; -.
DR OrthoDB; 1319907at2759; -.
DR PhylomeDB; Q8IUW3; -.
DR TreeFam; TF328840; -.
DR PathwayCommons; Q8IUW3; -.
DR SignaLink; Q8IUW3; -.
DR BioGRID-ORCS; 124044; 15 hits in 1076 CRISPR screens.
DR GenomeRNAi; 124044; -.
DR Pharos; Q8IUW3; Tdark.
DR PRO; PR:Q8IUW3; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8IUW3; protein.
DR Bgee; ENSG00000158792; Expressed in pancreatic ductal cell and 184 other tissues.
DR ExpressionAtlas; Q8IUW3; baseline and differential.
DR Genevisible; Q8IUW3; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR029745; SPATA2L.
DR PANTHER; PTHR15326:SF7; PTHR15326:SF7; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..424
FT /note="Spermatogenesis-associated protein 2-like protein"
FT /id="PRO_0000297670"
FT REGION 233..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BNN1"
FT VAR_SEQ 139..152
FT /note="VTALPPACQLVQVA -> LCWSQSAGLCRVHG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027332"
FT VAR_SEQ 153..424
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027333"
SQ SEQUENCE 424 AA; 46179 MW; BC52E883E8994BAA CRC64;
MGSSSLSEDY RQCLERELRR GRAGVCGDPS LRAVLWQILV EDFDLHGALQ DDALALLTDG
LWGRADLAPA LRGLARAFEL LELAAVHLYL LPWRKEFTTI KTFSGGYVHV LKGVLSDDLL
LKSFQKMGYV RRDSHRLMVT ALPPACQLVQ VALGCFALRL ECEILGEVLA QLGTSVLPAE
ELLQARRASG DVASCVAWLQ QRLAQDEEPP PLPPRGSPAA YRAPLDLYRD LQEDEGSEDA
SLYGEPSPGP DSPPAELAYR PPLWEQSAKL WGTGGRAWEP PAEELPQASS PPYGALEEGL
EPEPSAFSFL SLRRELSRPG DLATPESSAA ASPRRIRAEG VPASAYRSVS EPPGYQAHSC
LSPGALPTLC CDTCRQLHAA HCAALPACRP GHSLRVLLGD AQRRLWLQRA QMDTLLYNSP
GARP
