SPA2L_MOUSE
ID SPA2L_MOUSE Reviewed; 426 AA.
AC Q8BNN1; Q3UTL5; Q5DTL7;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Spermatogenesis-associated protein 2-like protein {ECO:0000305};
DE Short=SPATA2-like protein {ECO:0000305};
GN Name=Spata2l {ECO:0000312|MGI:MGI:1926029};
GN Synonyms=Kiaa4138 {ECO:0000303|Ref.2};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Brain cortex, Corpus striatum, and Dendritic cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-326, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BNN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BNN1-2; Sequence=VSP_027334, VSP_027335;
CC -!- SIMILARITY: Belongs to the SPATA2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90513.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK081234; BAC38172.1; -; mRNA.
DR EMBL; AK139339; BAE23965.1; -; mRNA.
DR EMBL; AK170267; BAE41672.1; -; mRNA.
DR EMBL; AK220503; BAD90513.1; ALT_INIT; mRNA.
DR CCDS; CCDS22752.1; -. [Q8BNN1-1]
DR RefSeq; NP_084452.2; NM_030176.2. [Q8BNN1-1]
DR RefSeq; XP_006531567.1; XM_006531504.3. [Q8BNN1-1]
DR RefSeq; XP_006531568.1; XM_006531505.3.
DR AlphaFoldDB; Q8BNN1; -.
DR SMR; Q8BNN1; -.
DR BioGRID; 219625; 1.
DR IntAct; Q8BNN1; 1.
DR MINT; Q8BNN1; -.
DR STRING; 10090.ENSMUSP00000130306; -.
DR iPTMnet; Q8BNN1; -.
DR PhosphoSitePlus; Q8BNN1; -.
DR MaxQB; Q8BNN1; -.
DR PaxDb; Q8BNN1; -.
DR PRIDE; Q8BNN1; -.
DR ProteomicsDB; 263302; -. [Q8BNN1-1]
DR ProteomicsDB; 263303; -. [Q8BNN1-2]
DR Antibodypedia; 30904; 362 antibodies from 20 providers.
DR DNASU; 78779; -.
DR Ensembl; ENSMUST00000098327; ENSMUSP00000095932; ENSMUSG00000033594. [Q8BNN1-1]
DR Ensembl; ENSMUST00000166768; ENSMUSP00000130306; ENSMUSG00000033594. [Q8BNN1-1]
DR GeneID; 78779; -.
DR KEGG; mmu:78779; -.
DR UCSC; uc009nup.1; mouse. [Q8BNN1-1]
DR CTD; 124044; -.
DR MGI; MGI:1926029; Spata2l.
DR VEuPathDB; HostDB:ENSMUSG00000033594; -.
DR eggNOG; ENOG502S1TH; Eukaryota.
DR GeneTree; ENSGT00530000063956; -.
DR HOGENOM; CLU_047839_0_0_1; -.
DR InParanoid; Q8BNN1; -.
DR OMA; QAHSCLA; -.
DR PhylomeDB; Q8BNN1; -.
DR TreeFam; TF328840; -.
DR BioGRID-ORCS; 78779; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BNN1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BNN1; protein.
DR Bgee; ENSMUSG00000033594; Expressed in caudate-putamen and 114 other tissues.
DR ExpressionAtlas; Q8BNN1; baseline and differential.
DR Genevisible; Q8BNN1; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR029745; SPATA2L.
DR PANTHER; PTHR15326:SF7; PTHR15326:SF7; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..426
FT /note="Spermatogenesis-associated protein 2-like protein"
FT /id="PRO_0000297671"
FT REGION 204..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 102..154
FT /note="TFSGGYVHVLKGVLSEELLTRSFQKMGYVRRDNHRLMVTTPPPACQLVQVAL
FT G -> LYNQVDLVDLGSAREEGLMGQQLCQDAADSPVEAADLHLATNQHTREEAGKWP
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027334"
FT VAR_SEQ 155..426
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027335"
FT CONFLICT 331
FT /note="G -> R (in Ref. 2; BAD90513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 46772 MW; 048152D184FC50CE CRC64;
MGSSSLSEDY RQCLERELRR GRAGVCGDPS LRAVLWQILV EDFDLHGALQ DDALALFTDG
LWGRADLAPA LQDLARAFEL LELAAVHLYL LPWRKEFTTI KTFSGGYVHV LKGVLSEELL
TRSFQKMGYV RRDNHRLMVT TPPPACQLVQ VALGCFALRL ECEILSEVLT QLGTSVLPAE
ELLRARRASG DVASCVAWLQ QRLAQDEEPP PLPPRGTPAT YGAPVDLYQD LQEDESSEAS
LYGEPSPGLD SPPVELAYRP PLWEQSAKLW GSGGQPWEPP ADDMHRASSP PYGALEEELE
PEPSAFSFLS LRRELSRSGD LAPPESPSSP GQASPRHRQA EAAASSAYGP AVEPLSYQAH
SCLSPGNLPT LCCDTCRQLH ATHCTALSAC RPTHSLRILL GDNQRRLWLQ RAQVDNLLYD
SPGAHP
