ID   SPA36_BOVIN             Reviewed;         414 AA.
AC   A2I7N2;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Serpin A3-6;
DE   Flags: Precursor;
GN   Name=SERPINA3-6 {ECO:0000312|EMBL:ABM55499.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RX   PubMed=18384666; DOI=10.1186/1471-2164-9-151;
RA   Pelissier P., Delourme D., Germot A., Blanchet X., Becila S., Maftah A.,
RA   Leveziel H., Ouali A., Bremaud L.;
RT   "An original SERPINA3 gene cluster: elucidation of genomic organization and
RT   gene expression in the Bos taurus 21q24 region.";
RL   BMC Genomics 9:151-151(2008).
CC   -!- FUNCTION: Serine protease inhibitor. {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC       chromaffin granule {ECO:0000250|UniProtKB:Q9TTE1}. Secreted
CC       {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000255}.
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DR   EMBL; EF153629; ABM55499.1; -; Genomic_DNA.
DR   RefSeq; NP_001139774.1; NM_001146302.1.
DR   AlphaFoldDB; A2I7N2; -.
DR   SMR; A2I7N2; -.
DR   MEROPS; I04.027; -.
DR   PRIDE; A2I7N2; -.
DR   GeneID; 100272171; -.
DR   CTD; 100272171; -.
DR   InParanoid; A2I7N2; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Glycoprotein; Protease inhibitor; Reference proteome;
KW   Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..414
FT                   /note="Serpin A3-6"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000401160"
FT   SITE            380..381
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250|UniProtKB:Q9TTE1"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        233
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        321
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   414 AA;  46390 MW;  5219AA0735B88A82 CRC64;
     MRTERVSPLL ALGILVAGLC SRVHCLPENV TPEEQHKVTS VDGHSLASSN TDFAFSLYKQ
     LALKDPNKNV IFSPLSVSIA LAFLSLGAHG PTVTEILEGL KFNLTETPET EIHQGFQHLL
     QTFNQPSNQL QLSVGNAIFV QEELKLLDKF IEDARVLYSS EAFPTNFRDP EAAKSLINDY
     VKNKTQGKIE ELFKDLSPRT ELVLVNYVYF KAQWKTRFDP KHTEKTEFHV SDNKTVEVPM
     MTLDLETPYF RDEELGCTLV ELTYTSNDSA LFILPDKGKM QDLEAKLTPE MLTRWRNSLQ
     PRRIHELYLP KFSIKSNYEL NDTLSQMGIK KIFTDADLSG ITGTADLVVS QVVHGAALDV
     DEEGTEGAAA TGIGIERTFL RIIVRVNRPF LIAVVLKDTQ SIIFLGKVTN PSEA