SPA37_BOVIN
ID SPA37_BOVIN Reviewed; 417 AA.
AC A2I7N3;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Serpin A3-7;
DE Flags: Precursor;
GN Name=SERPINA3-7 {ECO:0000312|EMBL:ABM55500.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RX PubMed=18384666; DOI=10.1186/1471-2164-9-151;
RA Pelissier P., Delourme D., Germot A., Blanchet X., Becila S., Maftah A.,
RA Leveziel H., Ouali A., Bremaud L.;
RT "An original SERPINA3 gene cluster: elucidation of genomic organization and
RT gene expression in the Bos taurus 21q24 region.";
RL BMC Genomics 9:151-151(2008).
CC -!- FUNCTION: Serine protease inhibitor. {ECO:0000250|UniProtKB:Q9TTE1}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9TTE1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC chromaffin granule {ECO:0000250|UniProtKB:Q9TTE1}. Secreted
CC {ECO:0000250|UniProtKB:Q9TTE1}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000255}.
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DR EMBL; EF153630; ABM55500.1; -; Genomic_DNA.
DR AlphaFoldDB; A2I7N3; -.
DR SMR; A2I7N3; -.
DR STRING; 9913.ENSBTAP00000011576; -.
DR MEROPS; I04.034; -.
DR PaxDb; A2I7N3; -.
DR PeptideAtlas; A2I7N3; -.
DR PRIDE; A2I7N3; -.
DR eggNOG; KOG2392; Eukaryota.
DR InParanoid; A2I7N3; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Glycoprotein; Protease inhibitor; Reference proteome;
KW Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..417
FT /note="Serpin A3-7"
FT /evidence="ECO:0000255"
FT /id="PRO_0000401161"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 417 AA; 46942 MW; 06DD58B2CFC1AC8D CRC64;
MRTERTSFLL ALGLLVSGFC SRVHCLPENV TPEEQHKGTS VDGHSLASSN TDFALSLYKQ
LALKDPNKNV IFSPLSISIA LAFLSLGAHD HTVTEILEGL KFNLTETPET EIHQGFQHLL
QTFNQPSNQL QLSVGNAMFA SEELKLLDKF RKDAEAFYAS EVLSTNFKDS EAAVKLINEY
VKNKTHGKIE KLFNDLDVLT NLILLNYIFF KAQWKTPFNP NHTYESEFHV SQNERVIVPM
MTLYLETPYF RDEELGCTLV ELTYTSNDSA LFILPDEGKM QDLEAKLTPE TLTRWRSSLQ
PRLIHRLRLP RFSISSHYQL KDILSQLGIK KIFTSDAGFS GITDDHKLAV SHVIHKAVLD
VGEEGTEGAA VTAVVMATSS LLHTLTVSFN RPFLLSIFCK ETQSIIFWGK VTNPKEA