ID   SPA37_BOVIN             Reviewed;         417 AA.
AC   A2I7N3;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Serpin A3-7;
DE   Flags: Precursor;
GN   Name=SERPINA3-7 {ECO:0000312|EMBL:ABM55500.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RX   PubMed=18384666; DOI=10.1186/1471-2164-9-151;
RA   Pelissier P., Delourme D., Germot A., Blanchet X., Becila S., Maftah A.,
RA   Leveziel H., Ouali A., Bremaud L.;
RT   "An original SERPINA3 gene cluster: elucidation of genomic organization and
RT   gene expression in the Bos taurus 21q24 region.";
RL   BMC Genomics 9:151-151(2008).
CC   -!- FUNCTION: Serine protease inhibitor. {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC       chromaffin granule {ECO:0000250|UniProtKB:Q9TTE1}. Secreted
CC       {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000255}.
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DR   EMBL; EF153630; ABM55500.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2I7N3; -.
DR   SMR; A2I7N3; -.
DR   STRING; 9913.ENSBTAP00000011576; -.
DR   MEROPS; I04.034; -.
DR   PaxDb; A2I7N3; -.
DR   PeptideAtlas; A2I7N3; -.
DR   PRIDE; A2I7N3; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; A2I7N3; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Glycoprotein; Protease inhibitor; Reference proteome;
KW   Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..417
FT                   /note="Serpin A3-7"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000401161"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        221
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  46942 MW;  06DD58B2CFC1AC8D CRC64;
     MRTERTSFLL ALGLLVSGFC SRVHCLPENV TPEEQHKGTS VDGHSLASSN TDFALSLYKQ
     LALKDPNKNV IFSPLSISIA LAFLSLGAHD HTVTEILEGL KFNLTETPET EIHQGFQHLL
     QTFNQPSNQL QLSVGNAMFA SEELKLLDKF RKDAEAFYAS EVLSTNFKDS EAAVKLINEY
     VKNKTHGKIE KLFNDLDVLT NLILLNYIFF KAQWKTPFNP NHTYESEFHV SQNERVIVPM
     MTLYLETPYF RDEELGCTLV ELTYTSNDSA LFILPDEGKM QDLEAKLTPE TLTRWRSSLQ
     PRLIHRLRLP RFSISSHYQL KDILSQLGIK KIFTSDAGFS GITDDHKLAV SHVIHKAVLD
     VGEEGTEGAA VTAVVMATSS LLHTLTVSFN RPFLLSIFCK ETQSIIFWGK VTNPKEA