SPA38_BOVIN
ID SPA38_BOVIN Reviewed; 418 AA.
AC A6QPQ2; A2I7N4;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Serpin A3-8;
DE Flags: Precursor;
GN Name=SERPINA3-8 {ECO:0000312|EMBL:AAI49428.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RX PubMed=18384666; DOI=10.1186/1471-2164-9-151;
RA Pelissier P., Delourme D., Germot A., Blanchet X., Becila S., Maftah A.,
RA Leveziel H., Ouali A., Bremaud L.;
RT "An original SERPINA3 gene cluster: elucidation of genomic organization and
RT gene expression in the Bos taurus 21q24 region.";
RL BMC Genomics 9:151-151(2008).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI49428.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford {ECO:0000312|EMBL:AAI49428.1};
RC TISSUE=Fetal liver {ECO:0000312|EMBL:AAI49428.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine protease inhibitor. {ECO:0000250|UniProtKB:Q9TTE1}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9TTE1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC chromaffin granule {ECO:0000250|UniProtKB:Q9TTE1}. Secreted
CC {ECO:0000250|UniProtKB:Q9TTE1}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000255}.
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DR EMBL; EF153631; ABM55501.1; -; Genomic_DNA.
DR EMBL; BC149427; AAI49428.1; -; mRNA.
DR RefSeq; NP_001075181.1; NM_001081712.1.
DR AlphaFoldDB; A6QPQ2; -.
DR SMR; A6QPQ2; -.
DR STRING; 9913.ENSBTAP00000009261; -.
DR PaxDb; A6QPQ2; -.
DR PeptideAtlas; A6QPQ2; -.
DR PRIDE; A6QPQ2; -.
DR GeneID; 505820; -.
DR KEGG; bta:505820; -.
DR CTD; 505820; -.
DR eggNOG; KOG2392; Eukaryota.
DR InParanoid; A6QPQ2; -.
DR OrthoDB; 1124079at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Glycoprotein; Protease inhibitor; Reference proteome;
KW Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..418
FT /note="Serpin A3-8"
FT /evidence="ECO:0000255"
FT /id="PRO_0000401162"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 31
FT /note="T -> A (in Ref. 1; ABM55501)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="L -> P (in Ref. 1; ABM55501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 46964 MW; 7508C6B8978C92E1 CRC64;
MRAERMSPLL ALGLLVSGLC SRVHCLPENV TPEERHKGTS VDGHSLASSN TDFAFSLYKQ
LALKNPNKNV IFSPLSISIA LAFLSLGARG PTVTEILEGL KFNLTETLER EIHQGFQHLL
QMLSRPSNEL QLSVGNTMFV QEQLKLLDKF REDALALYTS EAFSTNFKDP ETAKSLINDY
VKNKTRGKIV DLFKDLDPLT KVILVNYIYF KAQWRTPFDP KQTYKSQFHV SKNKTVEVPM
MSIGDLVTPY FRDEELDCTL VELTYTSNDS ALFILPDEGK MQDLEAKLIP EMLTRWRESL
YPRGIHELNL PRFSIATDYK LKDILSQLEI KKVFTQEADL SGITDDHELE VSQVVHKAVL
DVGEEGTEGA AATGVKVGIT SINNHIPLSF NRPFLIAIVL KDTQSIIFLG KVTNPSQA