ID   SPA38_BOVIN             Reviewed;         418 AA.
AC   A6QPQ2; A2I7N4;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Serpin A3-8;
DE   Flags: Precursor;
GN   Name=SERPINA3-8 {ECO:0000312|EMBL:AAI49428.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RX   PubMed=18384666; DOI=10.1186/1471-2164-9-151;
RA   Pelissier P., Delourme D., Germot A., Blanchet X., Becila S., Maftah A.,
RA   Leveziel H., Ouali A., Bremaud L.;
RT   "An original SERPINA3 gene cluster: elucidation of genomic organization and
RT   gene expression in the Bos taurus 21q24 region.";
RL   BMC Genomics 9:151-151(2008).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAI49428.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI49428.1};
RC   TISSUE=Fetal liver {ECO:0000312|EMBL:AAI49428.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serine protease inhibitor. {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC       chromaffin granule {ECO:0000250|UniProtKB:Q9TTE1}. Secreted
CC       {ECO:0000250|UniProtKB:Q9TTE1}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000255}.
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DR   EMBL; EF153631; ABM55501.1; -; Genomic_DNA.
DR   EMBL; BC149427; AAI49428.1; -; mRNA.
DR   RefSeq; NP_001075181.1; NM_001081712.1.
DR   AlphaFoldDB; A6QPQ2; -.
DR   SMR; A6QPQ2; -.
DR   STRING; 9913.ENSBTAP00000009261; -.
DR   PaxDb; A6QPQ2; -.
DR   PeptideAtlas; A6QPQ2; -.
DR   PRIDE; A6QPQ2; -.
DR   GeneID; 505820; -.
DR   KEGG; bta:505820; -.
DR   CTD; 505820; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; A6QPQ2; -.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR   GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Glycoprotein; Protease inhibitor; Reference proteome;
KW   Secreted; Serine protease inhibitor; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..418
FT                   /note="Serpin A3-8"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000401162"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        233
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        31
FT                   /note="T -> A (in Ref. 1; ABM55501)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108
FT                   /note="L -> P (in Ref. 1; ABM55501)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  46964 MW;  7508C6B8978C92E1 CRC64;
     MRAERMSPLL ALGLLVSGLC SRVHCLPENV TPEERHKGTS VDGHSLASSN TDFAFSLYKQ
     LALKNPNKNV IFSPLSISIA LAFLSLGARG PTVTEILEGL KFNLTETLER EIHQGFQHLL
     QMLSRPSNEL QLSVGNTMFV QEQLKLLDKF REDALALYTS EAFSTNFKDP ETAKSLINDY
     VKNKTRGKIV DLFKDLDPLT KVILVNYIYF KAQWRTPFDP KQTYKSQFHV SKNKTVEVPM
     MSIGDLVTPY FRDEELDCTL VELTYTSNDS ALFILPDEGK MQDLEAKLIP EMLTRWRESL
     YPRGIHELNL PRFSIATDYK LKDILSQLEI KKVFTQEADL SGITDDHELE VSQVVHKAVL
     DVGEEGTEGA AATGVKVGIT SINNHIPLSF NRPFLIAIVL KDTQSIIFLG KVTNPSQA