ID   SPA5L_XENTR             Reviewed;         593 AA.
AC   Q0VA52;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Ribosome biogenesis protein SPATA5L1 {ECO:0000305};
DE            EC=3.6.4.10 {ECO:0000250|UniProtKB:P32794};
DE   AltName: Full=Spermatogenesis-associated protein 5-like protein 1;
GN   Name=spata5l1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent chaperone, which plays an essential role in the
CC       cytoplasmic maturation steps of pre-60S ribosomal particles by
CC       promoting the release of shuttling protein RSL24D1/RLP24 from the pre-
CC       ribosomal particles. {ECO:0000250|UniProtKB:Q9BVQ7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10;
CC         Evidence={ECO:0000250|UniProtKB:P32794};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BVQ7}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BVQ7}.
CC       Nucleus {ECO:0000250|UniProtKB:D4A2B7}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. AFG2 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121246; AAI21247.1; -; mRNA.
DR   RefSeq; NP_001072787.1; NM_001079319.1.
DR   AlphaFoldDB; Q0VA52; -.
DR   SMR; Q0VA52; -.
DR   STRING; 8364.ENSXETP00000054098; -.
DR   DNASU; 780248; -.
DR   GeneID; 780248; -.
DR   KEGG; xtr:780248; -.
DR   CTD; 79029; -.
DR   Xenbase; XB-GENE-967079; spata5l1.
DR   InParanoid; Q0VA52; -.
DR   OrthoDB; 194195at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:1990275; F:preribosome binding; ISS:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 2.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Hydrolase; Nucleotide-binding;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis.
FT   CHAIN           1..593
FT                   /note="Ribosome biogenesis protein SPATA5L1"
FT                   /id="PRO_0000330588"
FT   BINDING         232..239
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         498..505
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   593 AA;  64731 MW;  F4115201F34AD2A4 CRC64;
     MDTVLKCLPS NPDDHCSQRC RLGPKAMALI GAKVGFPVLV SLQSGSCLCT AWPRRDLCDG
     FVQADYMCST SHKPMAVFKD TGICLNQIKS MASTKLRKVS VKVVVRSLDV KRATSEAALL
     ETVRDLLRNV FVLNDYVLSV NADSPVVHIE ILDTDPATSN AGLITGKTSI VIKEVITLEW
     YKHKLQEAPQ LKVAAMDDTC ASLKEIIHMP LHYPETMHKL GLPCPKGVLL IGPPGVGKTL
     LVKAVAREVG AYVIGLSGPA IHGSRPGESE ENLRKIFEKA REAACSGPAL LFIDEVDALC
     PKRGHSNSAP ENRVVAQLLT LMDGIDSDNK MVTVAATSRP DAIDPALRRP GRFDREVIIG
     TPTHKQRQAI LEMMISNMPT DRDVDAAALA DVTVGYVGAD LTALCRDAAM QAVLQASLDS
     LCNLVSRAHF YEAFKRIRPS SARSSIGRVE FKPVHWEHIG GLEDIKHKLR QSIEWPMKYP
     EAFSRMGLTP PKGVLLYGPP GCAKTTLVKA VATSCHCSFF SISAADLFSP YVGDSEKTLA
     QVSNRCSDKR GLALQPLFSL MKLMPWWGPD QKVEQDLGSR KGSFLFSLMS WMA