SPA9_MOUSE
ID SPA9_MOUSE Reviewed; 418 AA.
AC Q9D7D2;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Serpin A9;
DE Flags: Precursor;
GN Name=Serpina9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR EMBL; AK009343; BAB26230.1; -; mRNA.
DR CCDS; CCDS26144.1; -.
DR RefSeq; NP_082273.1; NM_027997.2.
DR RefSeq; XP_006516304.1; XM_006516241.1.
DR RefSeq; XP_006516305.1; XM_006516242.2.
DR AlphaFoldDB; Q9D7D2; -.
DR SMR; Q9D7D2; -.
DR STRING; 10090.ENSMUSP00000058535; -.
DR GlyGen; Q9D7D2; 3 sites.
DR iPTMnet; Q9D7D2; -.
DR PhosphoSitePlus; Q9D7D2; -.
DR PaxDb; Q9D7D2; -.
DR PRIDE; Q9D7D2; -.
DR ProteomicsDB; 263309; -.
DR Antibodypedia; 56037; 168 antibodies from 25 providers.
DR DNASU; 71907; -.
DR Ensembl; ENSMUST00000058464; ENSMUSP00000058535; ENSMUSG00000058260.
DR GeneID; 71907; -.
DR KEGG; mmu:71907; -.
DR UCSC; uc007owo.1; mouse.
DR CTD; 327657; -.
DR MGI; MGI:1919157; Serpina9.
DR VEuPathDB; HostDB:ENSMUSG00000058260; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000162880; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; Q9D7D2; -.
DR OMA; NCSVLQM; -.
DR OrthoDB; 1124079at2759; -.
DR PhylomeDB; Q9D7D2; -.
DR TreeFam; TF343201; -.
DR BioGRID-ORCS; 71907; 5 hits in 73 CRISPR screens.
DR PRO; PR:Q9D7D2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D7D2; protein.
DR Bgee; ENSMUSG00000058260; Expressed in striatum and 22 other tissues.
DR ExpressionAtlas; Q9D7D2; baseline and differential.
DR Genevisible; Q9D7D2; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0010951; P:negative regulation of endopeptidase activity; IBA:GO_Central.
DR Gene3D; 2.30.39.10; -; 1.
DR Gene3D; 3.30.497.10; -; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; PTHR11461; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; SSF56574; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..418
FT /note="Serpin A9"
FT /id="PRO_0000041972"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 418 AA; 46894 MW; 4CFA144E99381D2D CRC64;
MGSSSFYRVL LLVGFCAPIF CMLSSNPYNQ ESSHLPSMKK NPASQVSPSN TRFSFLLYQR
LAQENPGQNI LFSPVSISTS LAMLSLGARS ATKTQILRTL GFNFTWVSEP TIHMGFEYLV
RSLNKCHQGR ELRMGSVLFI RKELQLQATF LDRVKKLYGA KVFSEDFSNA ATAQAQINSY
VEKETKGKVV DVIQDLDSQT AMVLVNHIFF KANWTQPFST ANTNKSFPFL LSKGTTVHVP
MMHQTESFAF GVDKELGCSI LQMDYRGDAV AFFVLPGKGK MRQLEKSLSA RRLRKWSRSL
QKRWIKVFIP KFSISASYNL ETILPKMGIR DAFNSNADFS GITKTHFLQV SKAAHKAVLD
VSEEGTEAAA ATTTKLIVRS RDTPSSIIAF KEPFLILLLD KNTESVLFLG KVENPRKM
