ID   SPAM_SHIFL              Reviewed;         112 AA.
AC   P0A1K3; P40708; P81997; P96019; Q9AFS0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Surface presentation of antigens protein SpaM;
DE   AltName: Full=Spa13 protein;
GN   Name=spaM; Synonyms=spa13; OrderedLocusNames=CP0150;
OS   Shigella flexneri.
OG   Plasmid pWR100, Plasmid pMYSH6000, Plasmid pINV_F6_M1382, and
OG   Plasmid pCP301.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=1312536; DOI=10.1128/jb.174.6.1990-2001.1992;
RA   Venkatesan M.M., Buysse J.M., Oaks E.V.;
RT   "Surface presentation of Shigella flexneri invasion plasmid antigens
RT   requires the products of the spa locus.";
RL   J. Bacteriol. 174:1990-2001(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=YSH6000 / Serotype 2a; PLASMID=pMYSH6000;
RX   PubMed=8385666; DOI=10.1128/jb.175.8.2334-2346.1993;
RA   Sasakawa C., Komatsu K., Tobe T., Suzuki T., Yoshikawa M.;
RT   "Eight genes in region 5 that form an operon are essential for invasion of
RT   epithelial cells by Shigella flexneri 2a.";
RL   J. Bacteriol. 175:2334-2346(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x;
RA   Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H.,
RA   Kunst F., Sansonetti P.J., Parsot C.;
RT   "The virulence plasmid pWR100 and the repertoire of proteins secreted by
RT   the type III secretion apparatus of Shigella flexneri.";
RL   Mol. Microbiol. 38:760-771(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001;
RA   Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V.,
RA   Blattner F.R.;
RT   "Complete DNA sequence and analysis of the large virulence plasmid of
RT   Shigella flexneri.";
RL   Infect. Immun. 69:3271-3285(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M1382 / Serotype 6; PLASMID=pINV_F6_M1382;
RX   PubMed=14573649; DOI=10.1128/iai.71.11.6298-6306.2003;
RA   Lan R., Stevenson G., Reeves P.R.;
RT   "Comparison of two major forms of the Shigella virulence plasmid pINV:
RT   positive selection is a major force driving the divergence.";
RL   Infect. Immun. 71:6298-6306(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a; PLASMID=pCP301;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
CC   -!- FUNCTION: Required for surface presentation of invasion plasmid
CC       antigens. Could play a role in preserving the translocation competence
CC       of the ipa antigens. Required for invasion.
CC   -!- SIMILARITY: Belongs to the SpaM family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK18469.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M81458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; D13663; BAA02826.1; -; Genomic_DNA.
DR   EMBL; AL391753; CAC05825.1; -; Genomic_DNA.
DR   EMBL; AF348706; AAK18469.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AY206439; AAP79013.1; -; Genomic_DNA.
DR   EMBL; AF386526; AAL72555.1; -; Genomic_DNA.
DR   PIR; D49846; D49846.
DR   RefSeq; NP_858283.1; NC_004851.1.
DR   RefSeq; WP_000387670.1; NZ_UIQL01000031.1.
DR   RefSeq; YP_009062507.1; NC_024996.1.
DR   AlphaFoldDB; P0A1K3; -.
DR   SMR; P0A1K3; -.
DR   STRING; 198214.CP0150; -.
DR   TCDB; 3.A.6.1.2; the type iii (virulence-related) secretory pathway (iiisp) family.
DR   EnsemblBacteria; AAL72555; AAL72555; SF_p0150.
DR   GeneID; 1238258; -.
DR   KEGG; sfl:CP0150; -.
DR   PATRIC; fig|623.157.peg.5384; -.
DR   HOGENOM; CLU_2371225_0_0_6; -.
DR   OMA; MEPVGAQ; -.
DR   Proteomes; UP000001006; Plasmid pCP301.
PE   3: Inferred from homology;
KW   Plasmid; Reference proteome; Virulence.
FT   CHAIN           1..112
FT                   /note="Surface presentation of antigens protein SpaM"
FT                   /id="PRO_0000180935"
SQ   SEQUENCE   112 AA;  13207 MW;  FF4C6D4478453C98 CRC64;
     MEALDKRIIY FLQLENDLEP VGAQSVSQLF NTRRKIAIVK KHIIQYQSER ILLKGRIEEI
     QKDIDEANAS KRKLLHKESK ICKRIGLIKR NNFAKQLILD ELSQEDMKYG IR