ID   SPAN_SALTY              Reviewed;         336 AA.
AC   P40613;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Surface presentation of antigens protein SpaN;
DE   AltName: Full=Invasion protein InvJ;
GN   Name=spaN; Synonyms=invJ; OrderedLocusNames=STM2892;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8404849; DOI=10.1002/j.1460-2075.1993.tb06056.x;
RA   Groisman E.A., Ochman H.;
RT   "Cognate gene clusters govern invasion of host epithelial cells by
RT   Salmonella typhimurium and Shigella flexneri.";
RL   EMBO J. 12:3779-3787(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SR-11;
RX   PubMed=7752894; DOI=10.1111/j.1365-2958.1995.tb02218.x;
RA   Collazo C., Zierler M.K., Galan J.E.;
RT   "Functional analysis of the Salmonella typhimurium invasion genes invl and
RT   invJ and identification of a target of the protein secretion apparatus
RT   encoded in the inv locus.";
RL   Mol. Microbiol. 15:25-38(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S4194;
RA   Boyd E.F., Li J., Nelson K., Ochman H., Selander R.K.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in a secretory pathway responsible for the surface
CC       presentation of determinants needed for the entry of Salmonella species
CC       into mammalian cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SpaN family. {ECO:0000305}.
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DR   EMBL; X73525; CAA51923.1; -; Genomic_DNA.
DR   EMBL; U10872; AAA83431.1; -; Genomic_DNA.
DR   EMBL; U43300; AAC44991.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21772.1; -; Genomic_DNA.
DR   PIR; S37306; S37306.
DR   RefSeq; NP_461813.1; NC_003197.2.
DR   RefSeq; WP_000503098.1; NC_003197.2.
DR   AlphaFoldDB; P40613; -.
DR   STRING; 99287.STM2892; -.
DR   TCDB; 3.A.6.1.3; the type iii (virulence-related) secretory pathway (iiisp) family.
DR   PaxDb; P40613; -.
DR   PRIDE; P40613; -.
DR   EnsemblBacteria; AAL21772; AAL21772; STM2892.
DR   GeneID; 1254415; -.
DR   KEGG; stm:STM2892; -.
DR   PATRIC; fig|99287.12.peg.3048; -.
DR   HOGENOM; CLU_826082_0_0_6; -.
DR   OMA; HCAPAKS; -.
DR   BioCyc; SENT99287:STM2892-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003066; Invas_InvJ.
DR   Pfam; PF02510; SPAN; 1.
DR   PIRSF; PIRSF020738; Invas_invJ; 1.
DR   PRINTS; PR01306; SSPANPROTEIN.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Virulence.
FT   CHAIN           1..336
FT                   /note="Surface presentation of antigens protein SpaN"
FT                   /id="PRO_0000180938"
FT   REGION          300..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  36438 MW;  327EC4AE358C9393 CRC64;
     MGDVSAVSSS GNILLPQQDE VGGLSEALKK AVEKHKTEYS GDKKDRDYGD AFVMHKETAL
     PLLLAAWRHG APAKSEHHNG NVSGLHHNGK SELRIAEKLL KVTAEKSVGL ISAEAKVDKS
     AALLSSKNRP LESVSGKKLS ADLKAVESVS EVTDNATGIS DDNIKALPGD NKAIAGEGVR
     KEGAPLARDV APARMAAANT GKPEDKDHKK VKDVSQLPLQ PTTIADLSQL TGGDEKMPLA
     AQSKPMMTIF PTADGVKGED SSLTYRFQRW GNDYSVNIQA RQAGEFSLIP SNTQVEHRLH
     DQWQNGNPQR WHLTRDDQQN PQQQQHRQQS GEEDDA