ID   SPAN_SHISO              Reviewed;         292 AA.
AC   P0A1K6; P35532;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Surface presentation of antigens protein SpaN;
DE   AltName: Full=Spa32 protein;
GN   Name=spaN; Synonyms=spa32;
OS   Shigella sonnei.
OG   Plasmid pINV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HW383;
RA   Arakawa E., Kato J., Ito K., Watanabe H.;
RT   "Comparison and high conservation of nucleotide sequences of spa-mxi
RT   regions between S.sonnei and S.flexneri -- identification of a new gene
RT   coding plausible membrane protein.";
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for surface presentation of invasion plasmid
CC       antigens. Could play a role in preserving the translocation competence
CC       of the ipa antigens. Required for invasion and for secretion of IpaB
CC       and IpaD proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SpaN family. {ECO:0000305}.
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DR   EMBL; D50601; BAA09160.1; -; Genomic_DNA.
DR   RefSeq; WP_001162455.1; NZ_WHSK01000261.1.
DR   AlphaFoldDB; P0A1K6; -.
DR   OMA; NESGNAD; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Membrane; Plasmid; Virulence.
FT   CHAIN           1..292
FT                   /note="Surface presentation of antigens protein SpaN"
FT                   /id="PRO_0000180940"
FT   REGION          129..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        19..292
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   292 AA;  32978 MW;  78A112B3D24AB63C CRC64;
     MALDNINLNF SSDKQIEKCE KLSSIDNIDS LVLKKKRKVE IPEYSLIASN YFTIDKHFEH
     KHDKGEIYSG IKNAFELRNE RATYSDIPES MAIKENILIP DQDIKAREKI NIGDMRGIFS
     YNKSGNADKN FERSHTSSVN PDNLLESDNR NGQIGLKNHS LSIDKNIADI ISLLNGSVAK
     SFELPVMNKN TADITPSMSL QEKSIVENDK NVFQKNSEMT YHFKQWGAGH SVSISVESGS
     FVLKPSDQFV GNKLDLILKQ DAEGNYRFDS SQHNKGNKNN STGYNEQSEE EC