ID   SPAO_SALTI              Reviewed;         303 AA.
AC   Q56022;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Surface presentation of antigens protein SpaO;
GN   Name=spaO; OrderedLocusNames=STY3014, t2793;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S3333;
RX   PubMed=7638176; DOI=10.1073/pnas.92.16.7252;
RA   Li J., Ochman H., Groisman E.A., Boyd E.F., Solomon F., Nelson K.,
RA   Selander R.K.;
RT   "Relationship between evolutionary rate and cellular location among the
RT   Inv/Spa invasion proteins of Salmonella enterica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:7252-7256(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Involved in a secretory pathway responsible for the surface
CC       presentation of determinants needed for the entry of Salmonella species
CC       into mammalian cells.
CC   -!- SIMILARITY: Belongs to the FliN/MopA/SpaO family. {ECO:0000305}.
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DR   EMBL; U29363; AAC43860.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD05998.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70354.1; -; Genomic_DNA.
DR   RefSeq; NP_457285.1; NC_003198.1.
DR   RefSeq; WP_000058738.1; NZ_WSUR01000005.1.
DR   AlphaFoldDB; Q56022; -.
DR   SMR; Q56022; -.
DR   STRING; 220341.16503969; -.
DR   EnsemblBacteria; AAO70354; AAO70354; t2793.
DR   KEGG; stt:t2793; -.
DR   KEGG; sty:STY3014; -.
DR   PATRIC; fig|220341.7.peg.3068; -.
DR   eggNOG; COG1886; Bacteria.
DR   HOGENOM; CLU_077609_0_0_6; -.
DR   OMA; NNFAYAV; -.
DR   PHI-base; PHI:643; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR   Gene3D; 2.30.330.10; -; 1.
DR   InterPro; IPR001543; FliN-like_C.
DR   InterPro; IPR036429; SpoA-like_sf.
DR   InterPro; IPR003283; T3SS_OMP_SpaO.
DR   InterPro; IPR013385; T3SS_SpaO/YscQ/SpaO.
DR   Pfam; PF01052; FliMN_C; 1.
DR   PRINTS; PR01339; TYPE3OMOPROT.
DR   SUPFAM; SSF101801; SSF101801; 1.
DR   TIGRFAMs; TIGR02551; SpaO_YscQ; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..303
FT                   /note="Surface presentation of antigens protein SpaO"
FT                   /id="PRO_0000184125"
SQ   SEQUENCE   303 AA;  33764 MW;  B32E0E0F1D7728C4 CRC64;
     MSLRVRQIDR REWLLAQTAT ECQRHGREAT LEYPTRQGMW VRLSDAEKRW SAWIKPGGWL
     EHVSPALAGA AVSAGAEHLV VPWLAATERP FELPVPHLSC RRLCVENPVP GSALPEGKLL
     HIMSDRGGLW FEHLPELPAV GGGRPKMLRW PLRFVIGSSD TQRSLLGRIG IGDVLLIRTS
     RAEVYCYAKK LGHFNRVEGG IIVETLDIQH IEEENNTTET AETLPGLNQL PVKLEFVLYR
     KNVTLAELEA MGQQQLLSLP TNVELNVEIM ANGVLLGNGE LVQMNDTLGV EIHEWLSESG
     NGE