SPAO_SALTY
ID SPAO_SALTY Reviewed; 303 AA.
AC P40699;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Surface presentation of antigens protein SpaO;
GN Name=spaO; OrderedLocusNames=STM2891;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8404849; DOI=10.1002/j.1460-2075.1993.tb06056.x;
RA Groisman E.A., Ochman H.;
RT "Cognate gene clusters govern invasion of host epithelial cells by
RT Salmonella typhimurium and Shigella flexneri.";
RL EMBO J. 12:3779-3787(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Involved in a secretory pathway responsible for the surface
CC presentation of determinants needed for the entry of Salmonella species
CC into mammalian cells.
CC -!- SIMILARITY: Belongs to the FliN/MopA/SpaO family. {ECO:0000305}.
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DR EMBL; X73525; CAA51924.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21771.1; -; Genomic_DNA.
DR PIR; S37307; S37307.
DR RefSeq; NP_461812.1; NC_003197.2.
DR RefSeq; WP_000058734.1; NC_003197.2.
DR PDB; 4YX1; X-ray; 1.35 A; A/B=232-297.
DR PDB; 4YX5; X-ray; 2.90 A; A=145-213, B=232-297.
DR PDB; 4YX7; X-ray; 2.00 A; A/D=145-213, B/E=232-297.
DR PDB; 4YXA; X-ray; 2.35 A; A/D=145-213, B/E=232-297.
DR PDBsum; 4YX1; -.
DR PDBsum; 4YX5; -.
DR PDBsum; 4YX7; -.
DR PDBsum; 4YXA; -.
DR AlphaFoldDB; P40699; -.
DR SASBDB; P40699; -.
DR SMR; P40699; -.
DR STRING; 99287.STM2891; -.
DR TCDB; 3.A.6.1.3; the type iii (virulence-related) secretory pathway (iiisp) family.
DR PaxDb; P40699; -.
DR EnsemblBacteria; AAL21771; AAL21771; STM2891.
DR GeneID; 1254414; -.
DR KEGG; stm:STM2891; -.
DR PATRIC; fig|99287.12.peg.3047; -.
DR HOGENOM; CLU_077609_0_0_6; -.
DR OMA; NNFAYAV; -.
DR BioCyc; SENT99287:STM2891-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0050918; P:positive chemotaxis; IBA:GO_Central.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR Gene3D; 2.30.330.10; -; 1.
DR InterPro; IPR001543; FliN-like_C.
DR InterPro; IPR036429; SpoA-like_sf.
DR InterPro; IPR003283; T3SS_OMP_SpaO.
DR InterPro; IPR013385; T3SS_SpaO/YscQ/SpaO.
DR Pfam; PF01052; FliMN_C; 1.
DR PRINTS; PR01339; TYPE3OMOPROT.
DR SUPFAM; SSF101801; SSF101801; 1.
DR TIGRFAMs; TIGR02551; SpaO_YscQ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Virulence.
FT CHAIN 1..303
FT /note="Surface presentation of antigens protein SpaO"
FT /id="PRO_0000184126"
FT STRAND 149..162
FT /evidence="ECO:0007829|PDB:4YX7"
FT TURN 166..168
FT /evidence="ECO:0007829|PDB:4YX7"
FT STRAND 174..176
FT /evidence="ECO:0007829|PDB:4YX7"
FT STRAND 179..186
FT /evidence="ECO:0007829|PDB:4YX7"
FT STRAND 189..197
FT /evidence="ECO:0007829|PDB:4YX7"
FT STRAND 200..203
FT /evidence="ECO:0007829|PDB:4YX7"
FT STRAND 232..243
FT /evidence="ECO:0007829|PDB:4YX1"
FT HELIX 245..252
FT /evidence="ECO:0007829|PDB:4YX1"
FT STRAND 255..258
FT /evidence="ECO:0007829|PDB:4YX1"
FT HELIX 263..265
FT /evidence="ECO:0007829|PDB:4YX1"
FT STRAND 267..271
FT /evidence="ECO:0007829|PDB:4YX1"
FT STRAND 274..283
FT /evidence="ECO:0007829|PDB:4YX1"
FT STRAND 285..295
FT /evidence="ECO:0007829|PDB:4YX1"
SQ SEQUENCE 303 AA; 33794 MW; 608D54341D77B1E0 CRC64;
MSLRVRQIDR REWLLAQTAT ECQRHGREAT LEYPTRQGMW VRLSDAEKRW SAWIKPGDWL
EHVSPALAGA AVSAGAEHLV VPWLAATERP FELPVPHLSC RRLCVENPVP GSALPEGKLL
HIMSDRGGLW FEHLPELPAV GGGRPKMLRW PLRFVIGSSD TQRSLLGRIG IGDVLLIRTS
RAEVYCYAKK LGHFNRVEGG IIVETLDIQH IEEENNTTET AETLPGLNQL PVKLEFVLYR
KNVTLAELEA MGQQQLLSLP TNAELNVEIM ANGVLLGNGE LVQMNDTLGV EIHEWLSESG
NGE
