ID   SPAP_SALTI              Reviewed;         224 AA.
AC   Q56023;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Surface presentation of antigens protein SpaP;
GN   Name=spaP; OrderedLocusNames=STY3013, t2792;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S3333;
RX   PubMed=7638176; DOI=10.1073/pnas.92.16.7252;
RA   Li J., Ochman H., Groisman E.A., Boyd E.F., Solomon F., Nelson K.,
RA   Selander R.K.;
RT   "Relationship between evolutionary rate and cellular location among the
RT   Inv/Spa invasion proteins of Salmonella enterica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:7252-7256(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Involved in a secretory pathway responsible for the surface
CC       presentation of determinants needed for the entry of Salmonella species
CC       into mammalian cells.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FliP/MopC/SpaP family. {ECO:0000305}.
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DR   EMBL; U29363; AAC43861.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD05997.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70353.1; -; Genomic_DNA.
DR   RefSeq; NP_457284.1; NC_003198.1.
DR   RefSeq; WP_000526019.1; NZ_WSUR01000005.1.
DR   AlphaFoldDB; Q56023; -.
DR   SMR; Q56023; -.
DR   STRING; 220341.16503968; -.
DR   EnsemblBacteria; AAO70353; AAO70353; t2792.
DR   KEGG; stt:t2792; -.
DR   KEGG; sty:STY3013; -.
DR   PATRIC; fig|220341.7.peg.3067; -.
DR   eggNOG; COG4790; Bacteria.
DR   HOGENOM; CLU_042028_2_0_6; -.
DR   OMA; SIVLVMM; -.
DR   PHI-base; PHI:642; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR005838; T3SS_IM_P.
DR   InterPro; IPR005773; YopR.
DR   PANTHER; PTHR30587; PTHR30587; 1.
DR   Pfam; PF00813; FliP; 1.
DR   PRINTS; PR01302; TYPE3IMPPROT.
DR   TIGRFAMs; TIGR01102; yscR; 1.
DR   PROSITE; PS01060; FLIP_1; 1.
DR   PROSITE; PS01061; FLIP_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..224
FT                   /note="Surface presentation of antigens protein SpaP"
FT                   /id="PRO_0000191991"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  25262 MW;  0352C1D88DAECA24 CRC64;
     MGNDISLIAL LAFSTLLPFI IASGTCFVKF SIVFVMVRNA LGLQQIPSNM TLNSVALLLS
     MFVMWPIMHD AYVYFEDEDV TFNDISSLSK HVDEGLDGYR DYLIKYSDRE LVQFFENAQL
     KRQYGEETET VKRDKDEIEK PSIFALLPAY ALSEIKSAFK IGFYLYLPFV VVDLVVSSVL
     LALGMMMMSP VTISTPIKLV LFVALDGWTL LSKGLILQYM DIAT