SPAP_SALTY
ID SPAP_SALTY Reviewed; 224 AA.
AC P40700;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Surface presentation of antigens protein SpaP;
GN Name=spaP; OrderedLocusNames=STM2890;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8404849; DOI=10.1002/j.1460-2075.1993.tb06056.x;
RA Groisman E.A., Ochman H.;
RT "Cognate gene clusters govern invasion of host epithelial cells by
RT Salmonella typhimurium and Shigella flexneri.";
RL EMBO J. 12:3779-3787(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Involved in a secretory pathway responsible for the surface
CC presentation of determinants needed for the entry of Salmonella species
CC into mammalian cells.
CC -!- INTERACTION:
CC P40700; P40701: spaR; NbExp=2; IntAct=EBI-15880102, EBI-15880134;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FliP/MopC/SpaP family. {ECO:0000305}.
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DR EMBL; X73525; CAA51925.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21770.1; -; Genomic_DNA.
DR PIR; S37308; S37308.
DR RefSeq; NP_461811.1; NC_003197.2.
DR RefSeq; WP_000526016.1; NC_003197.2.
DR PDB; 6PEM; EM; 3.50 A; 0/1/2/3/4=1-224.
DR PDB; 6PEP; EM; 3.80 A; 0/1/2/3/4=1-224.
DR PDB; 6Q14; EM; 3.80 A; 0/1/2/3/4=1-224.
DR PDB; 6Q15; EM; 5.15 A; 0/1/2/3/4=1-224.
DR PDB; 6Q16; EM; 4.10 A; 0/1/2/3/4=1-224.
DR PDB; 7AGX; EM; 3.60 A; 1A/1B/1C/1D/1E=1-224.
DR PDB; 7AH9; EM; 3.30 A; 1A/1B/1C/1D/1E=1-224.
DR PDB; 7AHI; EM; 3.30 A; 1A/1B/1C/1D/1E=1-224.
DR PDBsum; 6PEM; -.
DR PDBsum; 6PEP; -.
DR PDBsum; 6Q14; -.
DR PDBsum; 6Q15; -.
DR PDBsum; 6Q16; -.
DR PDBsum; 7AGX; -.
DR PDBsum; 7AH9; -.
DR PDBsum; 7AHI; -.
DR AlphaFoldDB; P40700; -.
DR SMR; P40700; -.
DR DIP; DIP-59557N; -.
DR IntAct; P40700; 3.
DR STRING; 99287.STM2890; -.
DR TCDB; 3.A.6.1.3; the type iii (virulence-related) secretory pathway (iiisp) family.
DR PaxDb; P40700; -.
DR EnsemblBacteria; AAL21770; AAL21770; STM2890.
DR GeneID; 1254413; -.
DR KEGG; stm:STM2890; -.
DR PATRIC; fig|99287.12.peg.3046; -.
DR HOGENOM; CLU_042028_2_0_6; -.
DR OMA; SIVLVMM; -.
DR PhylomeDB; P40700; -.
DR BioCyc; SENT99287:STM2890-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR InterPro; IPR005838; T3SS_IM_P.
DR InterPro; IPR005773; YopR.
DR PANTHER; PTHR30587; PTHR30587; 1.
DR Pfam; PF00813; FliP; 1.
DR PRINTS; PR01302; TYPE3IMPPROT.
DR TIGRFAMs; TIGR01102; yscR; 1.
DR PROSITE; PS01060; FLIP_1; 1.
DR PROSITE; PS01061; FLIP_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Virulence.
FT CHAIN 1..224
FT /note="Surface presentation of antigens protein SpaP"
FT /id="PRO_0000191992"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 224 AA; 25232 MW; 18241189C38D4F20 CRC64;
MGNDISLIAL LAFSTLLPFI IASGTCFVKF SIVFVMVRNA LGLQQIPSNM TLNGVALLLS
MFVMWPIMHD AYVYFEDEDV TFNDISSLSK HVDEGLDGYR DYLIKYSDRE LVQFFENAQL
KRQYGEETET VKRDKDEIEK PSIFALLPAY ALSEIKSAFK IGFYLYLPFV VVDLVVSSVL
LALGMMMMSP VTISTPIKLV LFVALDGWTL LSKGLILQYM DIAT
